CAJ | 학술논문

目的：探讨急性颅脑损伤患者凝血功能变化与颅脑损伤严重程度和预后的关系，为诊断该病提供临床参考。方法将68例急性颅脑损伤患者分为轻、中、重型3组，分别测定活化部分凝血活酶时间（APTT）、血浆凝血酶原时间（PT）、纤维蛋白原（FBG），并与53例健康体检者进行对比。结果（1）急性颅脑损伤后轻型、中型和重型患者PT、APTT 水平明显高于对照组（ P＜0.05），且不同损伤程度组指标间也有差异（ P＜0.05）；（2）与 GOS1～3分组比较，GOS4～5分组 PT 和APTT水平显著改善，差异有统计学意义（P＜0.05）；（3）急性脑损伤患者PT、APTT 与其预后情况正相关（P＜0.01）。结论急性颅脑损伤患者凝血功能变化与颅脑损伤严重程度和预后密切相关。
목적：탐토급성로뇌손상환자응혈공능변화여로뇌손상엄중정도화예후적관계，위진단해병제공림상삼고。방법장68례급성로뇌손상환자분위경、중、중형3조，분별측정활화부분응혈활매시간（APTT）、혈장응혈매원시간（PT）、섬유단백원（FBG），병여53례건강체검자진행대비。결과（1）급성로뇌손상후경형、중형화중형환자PT、APTT 수평명현고우대조조（ P＜0.05），차불동손상정도조지표간야유차이（ P＜0.05）；（2）여 GOS1～3분조비교，GOS4～5분조 PT 화APTT수평현저개선，차이유통계학의의（P＜0.05）；（3）급성뇌손상환자PT、APTT 여기예후정황정상관（P＜0.01）。결론급성로뇌손상환자응혈공능변화여로뇌손상엄중정도화예후밀절상관。
Objective To explore The relationship between changes of coagulation functions and cerebral trauma severity and prognosis in patients with acute head injury ,and provide a reference for diagnosis of the disease .Methods 68 cases of pa-tients with acute head injury were divided into mild head injury group ,moderate head injury group and severe head injury group.APTT(activated partial thrombo-plastin time) ,PT(prothrombin time)and FBG (fibrinogen)were tested.And they were compared with healthy physical examination group (n=53) .Results ①The APTT and PT of mild ,moderate and severe head injury group were higher than those of control group(P<0 .05) ,and there was also a difference between any two groups. ②Compared with GOS1-3 group ,the APTT and PT of GOS4-5 group significantly improved(P<0 .05). ③APTT ,PT were posi-tively correlated with the prognosis.Conclusion The changes of coagulation functions of patients with acute head injury were intimately related to the severity and prognosis of patients with cerebral trauma.