CAJ | 학술논문

目的：提高对替加环素不良反应的认识，为临床合理用药提供参考。方法：通过检索文献，对替加环素不良反应病例中患者一般情况、原患疾病、不良反应类型、不良反应发生时间、治疗方法及转归等进行分析，同时报道1例使用替加环素后引起低血糖反应患者的诊疗过程，并结合文献进行分析。结果：共检索出10例替加环素不良反应的个案报道，其中胰腺炎8例，腹泻1例，凝血功能异常1例。本文报道的1例78岁男性患者诊断为重症肺炎、慢性阻塞性肺疾病、肺间质纤维化，机械通气过程中，痰培养多次为多重耐药鲍曼不动杆菌，在使用替加环素静脉滴注后出现顽固性低血糖。结论：应用替加环素时，应高度警惕其不良反应的发生，确保安全用药。
목적：제고대체가배소불량반응적인식，위림상합리용약제공삼고。방법：통과검색문헌，대체가배소불량반응병례중환자일반정황、원환질병、불량반응류형、불량반응발생시간、치료방법급전귀등진행분석，동시보도1례사용체가배소후인기저혈당반응환자적진료과정，병결합문헌진행분석。결과：공검색출10례체가배소불량반응적개안보도，기중이선염8례，복사1례，응혈공능이상1례。본문보도적1례78세남성환자진단위중증폐염、만성조새성폐질병、폐간질섬유화，궤계통기과정중，담배양다차위다중내약포만불동간균，재사용체가배소정맥적주후출현완고성저혈당。결론：응용체가배소시，응고도경척기불량반응적발생，학보안전용약。
Objective: To pay more attention to the adverse drug reactions (ADRs) induced by tigecycline and provide references for rational use of drugs. Methods:By reviewing the literatures, the ADRs induced by tigecyline were analyzed in respect of general data, primary disease of the patients, types of ADRs, occurrence time, therapeutic method, prognosis, etc. Meanwhile, a case of tigecycline-induced hypoglycemia was reported. Results: Ten ADRs cases induced by tigecycline were collected. Eight cases of them were pancreatitis, one case of diarrhea, one case of coagulation disorder. A 78-year-old male patient was diagnosed as severe pneumonia, chronic obstructive pulmonary disease, and pulmonary interstitial ifbrosis developing persistent hypoglycemia after intravenous infusion of tigecycline. During the mechanical ventilation, the result of sputum culture was multi-drugs resistant Acinetobacter Bauman. Conclusion:More attention should be paid to adverse events induced by tigecycline to ensure the safety of drug use in clinic.