中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2014年
2期
150-155
,共6页
韩志江%舒艳艳%吴志远%汪登斌%丁金旺
韓誌江%舒豔豔%吳誌遠%汪登斌%丁金旺
한지강%서염염%오지원%왕등빈%정금왕
原发性甲状旁腺功能亢进症%颈部%体层摄影术%X线计算机
原髮性甲狀徬腺功能亢進癥%頸部%體層攝影術%X線計算機
원발성갑상방선공능항진증%경부%체층섭영술%X선계산궤
Hyperparathyroidism%Neck%Tomography%X-ray computer
目的:评价CT对原发性甲状旁腺功能亢进( primary hyperparathyroidism ,PHPT)的诊断与鉴别诊断的价值。方法总结杭州市第一人民医院2004年1月至2012年3月和上海交通大学医学院附属瑞金医院2005年1月至2011年8月经手术及病理证实并具有完整临床及实验室资料的134例PHPT的CT资料,观察甲状旁腺增生(parathyroid hyperplasia,PH)、腺瘤(parathyroid adenoma,PA)、非典型腺瘤(a-typical adenoma ,APA)及腺癌( parathyroid carcinoma ,PC)的CT表现异同。结果134例共140枚病灶,单发130例130枚病灶,多发4例10枚病灶。 PH 17例22枚,直径0.6~2.8(1.2±0.6) cm;PA 105例106枚,直径0.3~3.2(1.1±0.6)cm;APA 10例10枚,直径0.9~3.3(2.1±0.7)cm;PC 2例2枚,直径2.1~3.0(2.6±0.6)cm。 CT显示124枚病灶位于气管食管沟或气管旁的甲状旁腺区,与甲状腺间均见线状低密度影,3枚病灶未显示,13枚病灶异位,其中9枚位于颈根部。 CT上显示的137枚病灶29.9%呈圆形(41/137)、38.0%椭圆形(52/137)、19.7%三角形(27/137)、12.4%条或柱状(17/137),平扫CT值30~66(45.0±12.3)HU,增强后59~209(121.8±32.7)HU。不同病理组病灶在位置(左上、左下、右上、右下或异位)(χ2=15.839)、线状低密度影(χ2=1.896)、形态(χ2=10.945)及CT平扫(χ2=0.915)和增强密度(χ2=6.165)之间差异无统计学意义( P >0.05);在病灶大小上差异有统计学意义(χ2=18.395, P<0.05),APA-PC组>PH-PA组。 CT表现为均匀强化99枚,因坏死而强化不均38枚,PH-PA组和APA-PC组坏死发生率差异有统计学意义(χ2=7.929,P<0.05),APA-PC组坏死发生率高于PH-PA组。结论气管食管沟或气管旁病灶,临床表现为PHPT症候群,对甲状旁腺占位性病变的定位诊断具有重要作用;多发病灶有助于PH的诊断,病灶体积越大及病灶内出现坏死提示APA或PC,而病灶位置(左上、左下、右上、右下或异位)、形态、密度、强化程度在定性诊断中均缺乏特异性,需结合临床及其他检查综合分析。
目的:評價CT對原髮性甲狀徬腺功能亢進( primary hyperparathyroidism ,PHPT)的診斷與鑒彆診斷的價值。方法總結杭州市第一人民醫院2004年1月至2012年3月和上海交通大學醫學院附屬瑞金醫院2005年1月至2011年8月經手術及病理證實併具有完整臨床及實驗室資料的134例PHPT的CT資料,觀察甲狀徬腺增生(parathyroid hyperplasia,PH)、腺瘤(parathyroid adenoma,PA)、非典型腺瘤(a-typical adenoma ,APA)及腺癌( parathyroid carcinoma ,PC)的CT錶現異同。結果134例共140枚病竈,單髮130例130枚病竈,多髮4例10枚病竈。 PH 17例22枚,直徑0.6~2.8(1.2±0.6) cm;PA 105例106枚,直徑0.3~3.2(1.1±0.6)cm;APA 10例10枚,直徑0.9~3.3(2.1±0.7)cm;PC 2例2枚,直徑2.1~3.0(2.6±0.6)cm。 CT顯示124枚病竈位于氣管食管溝或氣管徬的甲狀徬腺區,與甲狀腺間均見線狀低密度影,3枚病竈未顯示,13枚病竈異位,其中9枚位于頸根部。 CT上顯示的137枚病竈29.9%呈圓形(41/137)、38.0%橢圓形(52/137)、19.7%三角形(27/137)、12.4%條或柱狀(17/137),平掃CT值30~66(45.0±12.3)HU,增彊後59~209(121.8±32.7)HU。不同病理組病竈在位置(左上、左下、右上、右下或異位)(χ2=15.839)、線狀低密度影(χ2=1.896)、形態(χ2=10.945)及CT平掃(χ2=0.915)和增彊密度(χ2=6.165)之間差異無統計學意義( P >0.05);在病竈大小上差異有統計學意義(χ2=18.395, P<0.05),APA-PC組>PH-PA組。 CT錶現為均勻彊化99枚,因壞死而彊化不均38枚,PH-PA組和APA-PC組壞死髮生率差異有統計學意義(χ2=7.929,P<0.05),APA-PC組壞死髮生率高于PH-PA組。結論氣管食管溝或氣管徬病竈,臨床錶現為PHPT癥候群,對甲狀徬腺佔位性病變的定位診斷具有重要作用;多髮病竈有助于PH的診斷,病竈體積越大及病竈內齣現壞死提示APA或PC,而病竈位置(左上、左下、右上、右下或異位)、形態、密度、彊化程度在定性診斷中均缺乏特異性,需結閤臨床及其他檢查綜閤分析。
목적:평개CT대원발성갑상방선공능항진( primary hyperparathyroidism ,PHPT)적진단여감별진단적개치。방법총결항주시제일인민의원2004년1월지2012년3월화상해교통대학의학원부속서금의원2005년1월지2011년8월경수술급병리증실병구유완정림상급실험실자료적134례PHPT적CT자료,관찰갑상방선증생(parathyroid hyperplasia,PH)、선류(parathyroid adenoma,PA)、비전형선류(a-typical adenoma ,APA)급선암( parathyroid carcinoma ,PC)적CT표현이동。결과134례공140매병조,단발130례130매병조,다발4례10매병조。 PH 17례22매,직경0.6~2.8(1.2±0.6) cm;PA 105례106매,직경0.3~3.2(1.1±0.6)cm;APA 10례10매,직경0.9~3.3(2.1±0.7)cm;PC 2례2매,직경2.1~3.0(2.6±0.6)cm。 CT현시124매병조위우기관식관구혹기관방적갑상방선구,여갑상선간균견선상저밀도영,3매병조미현시,13매병조이위,기중9매위우경근부。 CT상현시적137매병조29.9%정원형(41/137)、38.0%타원형(52/137)、19.7%삼각형(27/137)、12.4%조혹주상(17/137),평소CT치30~66(45.0±12.3)HU,증강후59~209(121.8±32.7)HU。불동병리조병조재위치(좌상、좌하、우상、우하혹이위)(χ2=15.839)、선상저밀도영(χ2=1.896)、형태(χ2=10.945)급CT평소(χ2=0.915)화증강밀도(χ2=6.165)지간차이무통계학의의( P >0.05);재병조대소상차이유통계학의의(χ2=18.395, P<0.05),APA-PC조>PH-PA조。 CT표현위균균강화99매,인배사이강화불균38매,PH-PA조화APA-PC조배사발생솔차이유통계학의의(χ2=7.929,P<0.05),APA-PC조배사발생솔고우PH-PA조。결론기관식관구혹기관방병조,림상표현위PHPT증후군,대갑상방선점위성병변적정위진단구유중요작용;다발병조유조우PH적진단,병조체적월대급병조내출현배사제시APA혹PC,이병조위치(좌상、좌하、우상、우하혹이위)、형태、밀도、강화정도재정성진단중균결핍특이성,수결합림상급기타검사종합분석。
Objective To analyze CT characteristics of patients with primary parathyroid hyperplasia ( PPH) , parathyroid adenoma ( PA) , atypical parathyroid adenoma ( APA) , and parathyroid carcinoma ( PC) and to evaluate the value of CT in the diagnosis and differential diagnosis of primary hyperparathyroidism ( PHPT ) . Methods CT scan of 134 pathologically proved PHPT patients with complete clinical and laboratory data were retrorespectively analyzed .The similarities and differences of CT features in patients with PPH , PA, APA and PC were studied.Results Among 140 lesions in the 134 patients, 130 cases had solitary parathyroid mass and 4 cases had 10 parathyroid masses , including 22 lesions in 17 patients with PPH, with the diameter ranging from 0.6 cm to 2.8 cm(1.2 ±0.6)cm, 106 lesions in 105 patients with PA, with the diameter ranging from 0.3 cm to 3.2 cm (1.1 ±0.6)cm, 10 lesions in 10 patients with APA, with the diameter ranging from 0.9 cm to 3.3 cm(2.6 ± 0.6)cm, and 2 lesions in 2 patients with PC, with the diameter ranging from 2.1 cm to 3.0 cm(2.6 ±0.6)cm. 124 lesions were located in tracheo-esophageal groove or at the side of trachea on CT .The boundaries between the parathyroid and thyroid gland were low density .3 lesions did not appear .9 lesions were located at the area over the manubrium sterni among 13 lesions which were ectopic.CT images showed round (29.9%,41/137), oval (38.0%,52/137), triangular(19.7%, 27/137), and cylindrical(12.4%,17/137) tumors in 137 lesions.The density of lesions were 30-66 Hu(45.0 ±12.3)Hu on non-enhanced CT scan, and 59-209 Hu(121.8 ±32.7)Hu on enhanced scan .Different pathological lesions had no statistical difference on location ( left upper , left lower , right upper, right lower, ectopic)(χ2 =15.839), linear low density sign(χ2 =1.896), shape(χ2 =10.945), non-enhanced CT(χ2 =0.915) or enhancement CT(χ2 =6.165)(P>0.05).Different pathological lesions had statistical significance on sizes(χ2 =18.395, P<0.05).The diameter of APA-PC was bigger than that in PH-PA.99 lesions exhibited homogeneous enhancement , and 38 lesions exhibited heterogeneous enhancement .The necrosis rate of APA-PC was more than that of PH-PA(χ2 =7.929, P<0.05).Conclusions The lesions origi-nate from parathyroid if they are located in tracheo-esophageal groove or at the side of trachea with hyperparathy-roidism.Multiple lesions help in PH diagnosis .Large size and necrosis in lesions imply APA or PC .The location (left upper, left lower, right upper, right lower, ectopic), shape, density and the degree of enhancement of the lesions have not specificity for diagnosis of PHPT .