CAJ | 학술논문

目的：实现长爪沙鼠微生物质量升级和实验动物化目标，需对长爪沙鼠实施生物净化。方法在长爪沙鼠生物净化过程中，采取孕鼠选择和临产期判断、无菌剖宫产、仔鼠代乳以及独立通风笼盒（ IVC）饲养管理等措施，比较了ICR小鼠、SD大鼠、长爪沙鼠代乳和饲料中添加营养成分对仔鼠代乳的影响。结果本研究共实施长爪沙鼠无菌剖宫产达85胎次，通过ICR代乳鼠代乳并成功断乳167只。结论本研究顺利实现了长爪沙鼠生物净化，形成的关键技术有望为我国特色实验动物资源的生物净化提供参考。
목적：실현장조사서미생물질량승급화실험동물화목표，수대장조사서실시생물정화。방법재장조사서생물정화과정중，채취잉서선택화임산기판단、무균부궁산、자서대유이급독립통풍롱합（ IVC）사양관리등조시，비교료ICR소서、SD대서、장조사서대유화사료중첨가영양성분대자서대유적영향。결과본연구공실시장조사서무균부궁산체85태차，통과ICR대유서대유병성공단유167지。결론본연구순리실현료장조사서생물정화，형성적관건기술유망위아국특색실험동물자원적생물정화제공삼고。
Objective To obtain higher microbiological quality of Mongolian gerbil colonies and realization of experimental animalization by biological cleaning .Methods We conducted biological cleaning of Mongolian gerbils by selection of pregnant gerbils , perinatal judgment , aseptic Caesarean section , pup milk replacer and breeding in individually ventilated cages .We also compared the results by milk replacer for pup gerbils from lactating ICR mice , rats as well as gerbils.Results During the present study , 85 Caesarean operations were carried out and a total of 167 gerbils were weaned.Conclusions We have successfully achieved the biological cleaning from a Mongolian gerbil colony in Zhejiang province , and the key techniques may provide useful reference for biological cleaning of special laboratory animal species in China.