CAJ | 학술논문

目的：探讨高危型人乳头瘤病毒（HPV）DNA检测在筛查体检妇女宫颈癌前病变的临床应用价值。方法对2827例体检的已婚妇女做普通妇科检查后取样做超薄液基细胞学检查（TCT）和HPV 13种高危型DNA检测。结果高危型HPV的感染率为15．9％，3个不同年龄（＜30岁、30～45岁、＞45岁）体检组高危型HPV的感染率差异无统计学意义（P＞0．05）。83．4％的HPV高危型感染者1年内感染可清除。372例高危型HPV DNA检测阴性者至少2年未有癌前病变或宫颈癌发生。宫颈光滑或轻度糜烂者与宫颈糜烂Ⅱ度及以上者间高危型HPV感染率差异有统计学意义（P＜0．05）。TCT和高危型HPV DNA联合检测对宫颈癌前病变及宫颈癌的筛查率为72．7％。结论高危型HPV检测在妇女体检中的意义在于：高危型HPV感染的阴性预测和HPV的12个月以上的持续感染对宫颈癌的早期诊断、防治具有重要临床价值。TCT结合高危型HPV感染的检测更能有效地筛查宫颈癌及癌前病变。
목적：탐토고위형인유두류병독（HPV）DNA검측재사사체검부녀궁경암전병변적림상응용개치。방법대2827례체검적이혼부녀주보통부과검사후취양주초박액기세포학검사（TCT）화HPV 13충고위형DNA검측。결과고위형HPV적감염솔위15．9％，3개불동년령（＜30세、30～45세、＞45세）체검조고위형HPV적감염솔차이무통계학의의（P＞0．05）。83．4％적HPV고위형감염자1년내감염가청제。372례고위형HPV DNA검측음성자지소2년미유암전병변혹궁경암발생。궁경광활혹경도미란자여궁경미란Ⅱ도급이상자간고위형HPV감염솔차이유통계학의의（P＜0．05）。TCT화고위형HPV DNA연합검측대궁경암전병변급궁경암적사사솔위72．7％。결론고위형HPV검측재부녀체검중적의의재우：고위형HPV감염적음성예측화HPV적12개월이상적지속감염대궁경암적조기진단、방치구유중요림상개치。TCT결합고위형HPV감염적검측경능유효지사사궁경암급암전병변。
Objective To investigate the clinical application significance of high risk-type human papillomavirus (HPV)DNA detection to screen cervix precancerous lesion in healthy examination.Methods A total of 2 827 married females for healthy examination did the common gynecological examination.Their samples were detected for thinprep cytology test (TCT)and HPV 1 3 high risk-type DNA.Results The infection rate of high risk-type HPV was 1 5 .9%, and the infection rates of high risk-type HPV in 3 different groups (<30 years old,30-45 years old and >45 years old) had no statistical significance (P>0.05 ).The 83.4% females who had high risk-type HPV infection could remove virus infection in 1 year,and 372 females who had no high risk-type HPV infection did not have precancerous lesion or cervical cancer at least 2 years.The infection rate of high risk-type HPV in 2 groups of cervix slick or low-degree erosion and cervical erosionⅡor above degree had statistical significance (P<0.05 ).The screen rate of cervix precancerous lesion and cervical cancer using TCT and high risk-type HPV DNA combination detection was 72.7%.Conclusions The application of high risk-type HPV DNA detection in healthy examination has early diagnosis,prevention and treatment significance in the negative prediction of high risk-type HPV infection and persistent infection of HPV above 1 2 months.TCT and high risk-type HPV DNA combination detection can screen cervical cancer and cervix precancerous lesion efficiently.