CAJ | 학술논문

目的：探讨AECOPD患者D-2聚体、纤维蛋白原( Fg)临床水平变化意义及与血气相关性意义。方法测量AECOPD组70例及门诊健康体检组40例的血清D-2聚体、Fg水平及动脉血气指标。结果 AE-COPD组D-2聚体、Fg水平明显高于对照组( P<0．05)。相关性分析显示AECOPD组D-2聚体、Fg水平与动脉血二氧化碳分压(PaCO2)呈正相关(r =0．370,r =0．544,P <0．05),D-2聚体、Fg 水平与动脉血氧分压(PaO2)呈负相关(r=-0．277,r=-0．32,P<0．05)。结论 AECOPD组患者D-2聚体、Fg水平明显升高,监测D-2聚体、Fg水平可作为AECOPD预后指标。
목적：탐토AECOPD환자D-2취체、섬유단백원( Fg)림상수평변화의의급여혈기상관성의의。방법측량AECOPD조70례급문진건강체검조40례적혈청D-2취체、Fg수평급동맥혈기지표。결과 AE-COPD조D-2취체、Fg수평명현고우대조조( P<0．05)。상관성분석현시AECOPD조D-2취체、Fg수평여동맥혈이양화탄분압(PaCO2)정정상관(r =0．370,r =0．544,P <0．05),D-2취체、Fg 수평여동맥혈양분압(PaO2)정부상관(r=-0．277,r=-0．32,P<0．05)。결론 AECOPD조환자D-2취체、Fg수평명현승고,감측D-2취체、Fg수평가작위AECOPD예후지표。
Objective To investigate the changes of serum D-dimmer and plasma fibrinogen level and the results of correlated arteries blood gas analysis in patients with chronic obstructive pulmonary disease in acute period (AECOPD). Methods Serum D-dimmer and plasma fibrinogen level and blood gas analysis were measured in 70 patients with AECOPD and 40 healthy controls. Results The levels of serum D-dimmer and plasma fibrinogen were higher in the AECOPD group than in control group ( P<0. 05 ) . The concentrations of serum D-dimmer and plasma fibrinogen were positively correlated with arterial PaCO2(r=0. 370, r=0. 544, P<0. 05). There was negative cor-relation of serum D-dimmer and plasma fibrinogen level to arterial PaO2(r= -0. 277, r= -0. 32, P<0. 05). Con-clusion The detection of serum D-dimmer and plasma fibrinogen level can provide reliable indicators for the preven-tion of AECOPD.