CAJ | 학술논문

目的：调查医院新生儿下呼吸道感染患者标本产超广谱β-内酰胺酶（ESBLs）菌株的耐药性，以指导临床合理使用抗菌药物。方法对新生儿下呼吸道感染患者标本进行产 ESBLs菌株耐药性分析。结果产ESBLs菌株以肺炎克雷伯菌、大肠埃希菌为主，检出率分别为66．4％和38．1％。在多数情况下，产ESBLs菌株耐药率高于非产ESBLs菌株。产ESBLs菌株对青霉素类、第一代头孢菌素、第二代头孢菌素均广泛耐药，对头孢替坦、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦敏感性较好。所有菌株对亚胺培南、美洛培南全部敏感。结论新生儿下呼吸道感染产ESBLs菌株检出率较高，且耐药形势严峻，应引起临床重视。
목적：조사의원신생인하호흡도감염환자표본산초엄보β-내선알매（ESBLs）균주적내약성，이지도림상합리사용항균약물。방법대신생인하호흡도감염환자표본진행산 ESBLs균주내약성분석。결과산ESBLs균주이폐염극뢰백균、대장애희균위주，검출솔분별위66．4％화38．1％。재다수정황하，산ESBLs균주내약솔고우비산ESBLs균주。산ESBLs균주대청매소류、제일대두포균소、제이대두포균소균엄범내약，대두포체탄、고랍서림/타서파탄、두포고동/서파탄민감성교호。소유균주대아알배남、미락배남전부민감。결론신생인하호흡도감염산ESBLs균주검출솔교고，차내약형세엄준，응인기림상중시。
Objective To investigate the drug resistance of extended-spectrum beta-lactamase(ESBLs) producing pathogens cau-sing lower respiratory tract infection of neonates ,and to provide guidance for the rational use of antimicrobial agents .Methods The drug resistance of ESBLs producing pathogens isolated from lower respiratory tracts of neonates were analyzed .Results ESBLs producing strains in lower respiratory tract infection of neonates mostly were K lebsiella peumoniae and Escherichia coli ,and the detection rate were 66 .4% and 38 .1% respectively .In most cases ,the drug resistance rate of ESBLs producing strains were higher than that of non-ESBLs producing strains .ESBLs producing strains were resistant to penicillins ,first-generation cephalosporins , second-generation cephalosporins extensively ,and were sensitive to cefotetan ,piperacillin/tazobactam ,cefperazone/sulbactam .All the stains of K lebsiella peumoniae and Escherichia coli were sensitive to imipenem and meropenem .Conclusion Isolation rate of ESBLs producing strains is high in lower respiratory tract infection of neonates ,and the drug resistance situation is severe ,which should be concerned by clinicians .