甘肃医药
甘肅醫藥
감숙의약
Gansu Medical Journal
2014年
7期
494-500
,共7页
5-氨基酮戊酸光动力疗法%尿道尖锐湿疣%荟萃分析
5-氨基酮戊痠光動力療法%尿道尖銳濕疣%薈萃分析
5-안기동무산광동력요법%뇨도첨예습우%회췌분석
ALA-PDT%Condyloma acuminatum%Meta-analysis
目的：系统评价5-氨基酮戊酸光动力疗法（ALA-PDT）与常规物理疗法治疗尿道尖锐湿疣的临床疗效及安全性。方法：通过计算机检索系统检索有关ALA-PDT与物理疗法（CO2激光、冷冻、电灼）治疗尿道尖锐湿疣疗效的公开发表文献，并行Meta分析。结果：Meta分析显示ALA-PDT较常规物理疗法能明显降低尿道尖锐湿疣复发率，ALA-PDT与CO2激光、冷冻、电灼比较相对危险度（RR）分别为0.22，0.24，0.26；能降低治疗后不良反应发生率，ALA-PDT与CO2激光、电灼比较RR分别为0.30，0.12；但疣体清除率不如CO2激光、电灼， RR分别为0.97，0.95。结论：ALA-PDT可有效防止尿道尖锐湿疣复发并具有较好的安全性，但清除率不如物理疗法。
目的：繫統評價5-氨基酮戊痠光動力療法（ALA-PDT）與常規物理療法治療尿道尖銳濕疣的臨床療效及安全性。方法：通過計算機檢索繫統檢索有關ALA-PDT與物理療法（CO2激光、冷凍、電灼）治療尿道尖銳濕疣療效的公開髮錶文獻，併行Meta分析。結果：Meta分析顯示ALA-PDT較常規物理療法能明顯降低尿道尖銳濕疣複髮率，ALA-PDT與CO2激光、冷凍、電灼比較相對危險度（RR）分彆為0.22，0.24，0.26；能降低治療後不良反應髮生率，ALA-PDT與CO2激光、電灼比較RR分彆為0.30，0.12；但疣體清除率不如CO2激光、電灼， RR分彆為0.97，0.95。結論：ALA-PDT可有效防止尿道尖銳濕疣複髮併具有較好的安全性，但清除率不如物理療法。
목적：계통평개5-안기동무산광동력요법（ALA-PDT）여상규물리요법치료뇨도첨예습우적림상료효급안전성。방법：통과계산궤검색계통검색유관ALA-PDT여물리요법（CO2격광、냉동、전작）치료뇨도첨예습우료효적공개발표문헌，병행Meta분석。결과：Meta분석현시ALA-PDT교상규물리요법능명현강저뇨도첨예습우복발솔，ALA-PDT여CO2격광、냉동、전작비교상대위험도（RR）분별위0.22，0.24，0.26；능강저치료후불량반응발생솔，ALA-PDT여CO2격광、전작비교RR분별위0.30，0.12；단우체청제솔불여CO2격광、전작， RR분별위0.97，0.95。결론：ALA-PDT가유효방지뇨도첨예습우복발병구유교호적안전성，단청제솔불여물리요법。
To determine whether 5-amino-ketovaleric acid photodynamic(ALA-PDT) and physical therapy was an effective strategy in the treatment of patients with condyloma acuminatum (CA). Methods: Clinical literature about ALA-PDT and physical therapy (CO2 laser , liquid nitrogen freezing , electrocautery) were reviewed and identified for meta-analysis . Results: the meta-analysis showed ALA-PDT could lower the recurrence rate and adverse reaction of CA , Significant differences were found between ALA-PDT group and physical therapy group . Conclusion: ALA-PDT can decrease the recurrence rate of CA and improve the effect of patients with CA , but have a lower cure rate than physical therapy .
