中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
8期
847-850
,共4页
鲍小京%薄小萍%杨传高%陆卫红%羊镇宇
鮑小京%薄小萍%楊傳高%陸衛紅%羊鎮宇
포소경%박소평%양전고%륙위홍%양진우
非ST段抬高的急性冠脉综合征%磺达肝癸钠%低分子肝素
非ST段抬高的急性冠脈綜閤徵%磺達肝癸鈉%低分子肝素
비ST단태고적급성관맥종합정%광체간계납%저분자간소
Non-ST-segment elevation acute coronary syndromes%Fondaparinux%Low molecular weight heparin
目的 对比磺达肝癸钠和低分子肝素(LMWH)在老年非ST段抬高的急性冠状动脉综合征(NSTE-ACS)患者中应用的疗效和安全性.方法 将140例75岁以上NSTE-ACS患者随机分为两组,治疗组(70例)和对照组(70例),治疗组在常规治疗的基础上加用磺达肝癸钠,对照组在常规治疗的基础上加用LMWH.观察两组治疗效果以及4、7、30 d时心血管事件和治疗期间出血的发生率.结果 治疗组和对照组治疗有效率比较差异无统计学意义(x2=0.475,P＞0.05),4、7、30 d时心血管事件发生率比较差异亦无统计学意义(x2值分别0.257、0.475、0.317,P均＞0.05),轻微出血发生率比较治疗组低于对照组,差异有统计学意义(2.9％与31.4％,x2=20.115,P＜0.01).结论 应用磺达肝癸钠治疗老年NSTE-ACS患者有效性与LMWH相仿,但出血的发生率比LMWH低.
目的 對比磺達肝癸鈉和低分子肝素(LMWH)在老年非ST段抬高的急性冠狀動脈綜閤徵(NSTE-ACS)患者中應用的療效和安全性.方法 將140例75歲以上NSTE-ACS患者隨機分為兩組,治療組(70例)和對照組(70例),治療組在常規治療的基礎上加用磺達肝癸鈉,對照組在常規治療的基礎上加用LMWH.觀察兩組治療效果以及4、7、30 d時心血管事件和治療期間齣血的髮生率.結果 治療組和對照組治療有效率比較差異無統計學意義(x2=0.475,P＞0.05),4、7、30 d時心血管事件髮生率比較差異亦無統計學意義(x2值分彆0.257、0.475、0.317,P均＞0.05),輕微齣血髮生率比較治療組低于對照組,差異有統計學意義(2.9％與31.4％,x2=20.115,P＜0.01).結論 應用磺達肝癸鈉治療老年NSTE-ACS患者有效性與LMWH相倣,但齣血的髮生率比LMWH低.
목적 대비광체간계납화저분자간소(LMWH)재노년비ST단태고적급성관상동맥종합정(NSTE-ACS)환자중응용적료효화안전성.방법 장140례75세이상NSTE-ACS환자수궤분위량조,치료조(70례)화대조조(70례),치료조재상규치료적기출상가용광체간계납,대조조재상규치료적기출상가용LMWH.관찰량조치료효과이급4、7、30 d시심혈관사건화치료기간출혈적발생솔.결과 치료조화대조조치료유효솔비교차이무통계학의의(x2=0.475,P＞0.05),4、7、30 d시심혈관사건발생솔비교차이역무통계학의의(x2치분별0.257、0.475、0.317,P균＞0.05),경미출혈발생솔비교치료조저우대조조,차이유통계학의의(2.9％여31.4％,x2=20.115,P＜0.01).결론 응용광체간계납치료노년NSTE-ACS환자유효성여LMWH상방,단출혈적발생솔비LMWH저.
Objective To explore the efficiency and safety of fondaparinux and low molecular weight heparin(LMWH) on the elder patients with non-ST-segnent elevation acute coronary syndromes (NSTE-ACS).Methods One hundred and forty patients over 75 years old with NSTE-ACS were randomly divided into treatment group(n =70) and control group (n =70).Patients in treatment group were given the conventional treatment combined with fondaparinux,and in control group were given the basis of conventional treatment combined with LMWH.The therapeutic efficacy,the cardiovascular events at 4 d,7 d and 30 d during the treatment and bleeding incidence rate were observed.Reslts There was no statistically significant difference between the treatment group and control group in the total effective rate (x2 =0.475,P ＞ 0.05.Meanwhile,no significant differences were found between the two groups in cardiovascular events at 4 d,7 d and 30 d (x2 =0.257,0.475 and 0.317,P ＞0.05).The incidence rate of bleeding in treatment group was obviously lower than that in control group and there was statistically significant difference (2.9％ vs.31.4％ ; x2 =20.115,P ＜0.01).Conclusion The effectiveness of fondaparinux used in elderly patients with non-ST-segment elevation acute coronary syndromes is similar with LMWH,but the incidence rate of bleeding is lower than LMWH.
