CAJ | 학술논문

目的：探讨地佐辛用于无痛人工流产手术的对术后宫缩痛的影响。方法选择门诊ASAⅠ～Ⅱ级需行人工流产早孕妇女90例，随机分为3组，地佐辛组、芬太尼组及丙泊酚组，每组30例。地佐辛组于术前30 min肌肉注射地佐辛5 mg，入室后1 min内静脉注射丙泊酚1.5～2.5 mg/kg；芬太尼组1 min内静脉滴注芬太尼1.0μug/kg，3 min后于1 min内静脉注射丙泊酚1.5～2.5 mg/kg；丙泊酚组按芬太尼组方法给予丙泊酚。记录BP、HR、ECG、SpO2等生命体征，诱导时间、唤醒时间、定向力恢复时间，VAS、BCS评分以及不良反应的发生情况。结果地佐辛组SBP、DBP、HR下降低于其他2组（P＜0.05）；诱导时间、定向力恢复时间短于其他2组，丙泊酚用药量少于其他2组（P＜0.05）；VAS评分低于其他2组，血压下降、呼吸抑制等不良反应发生率低其他2组（P＜0.01）。结论地佐辛有效缓解术后宫缩痛、减少丙泊酚用量，不良反应少，安全有效，优于芬太尼联合丙泊酚，提高患者满意度。
목적：탐토지좌신용우무통인공유산수술적대술후궁축통적영향。방법선택문진ASAⅠ～Ⅱ급수행인공유산조잉부녀90례，수궤분위3조，지좌신조、분태니조급병박분조，매조30례。지좌신조우술전30 min기육주사지좌신5 mg，입실후1 min내정맥주사병박분1.5～2.5 mg/kg；분태니조1 min내정맥적주분태니1.0μug/kg，3 min후우1 min내정맥주사병박분1.5～2.5 mg/kg；병박분조안분태니조방법급여병박분。기록BP、HR、ECG、SpO2등생명체정，유도시간、환성시간、정향력회복시간，VAS、BCS평분이급불량반응적발생정황。결과지좌신조SBP、DBP、HR하강저우기타2조（P＜0.05）；유도시간、정향력회복시간단우기타2조，병박분용약량소우기타2조（P＜0.05）；VAS평분저우기타2조，혈압하강、호흡억제등불량반응발생솔저기타2조（P＜0.01）。결론지좌신유효완해술후궁축통、감소병박분용량，불량반응소，안전유효，우우분태니연합병박분，제고환자만의도。
Objective To investigate the efficacy and safety of Dezocine analgesia in painless abortion. Methods Ninety cases of outpatient with ASAⅠ~Ⅱgrade pregnancy and needed abortion were selected. All cases were divided into three groups according to random number table, and 30 cases in each group. Dezocine group (group D) were given intra-muscular dezocine (5 mg) injection 30 minutes before operation and followed by propofol after being sent to operation room. Conventional fentanyl analgesic group (group F) were given intravenous fentanyl drip (1.0 μg/kg) within a minute, and fol-lowed by propofol 1.5~2.5 mg/kg intravenously within a minute 3 minutes later. Group P were given propofol in the same way as group F. Then data were recorded including vital signs (BP, HR, ECG, SpO 2, et al), induction time, wake-up time, orientation recovery time, VAS, BCS scores, and adverse reactions. Results The falls of SBP, DBP, HR were lower in group D than that in group F and P (P< 0.05). The induction time, orientation recovery time were shorter than those in group F and group P. The dosage of propofol was less than that in Group F and P (P< 0.05). VAS score was lower than that of group P and F; and the the adverse reactions, such as hypotension, respiratory depression, were lower than those in group F and P (P< 0.01). Conclusion Dezocine can reduce postoperative contractive pains and propofol dosage, adverse reactions. It's safety profile and efficacy is better than fentanyl and propofol.