CAJ | 학술논문

目的：探讨替吉奥胶囊（S-1）治疗老年晚期胃癌的有效性和不良反应。方法选择在新疆医科大学附属肿瘤医院接受治疗的经病理证实的60例老年晚期胃癌病人，给予国产替吉奥胶囊单药口服化疗。结果60例患者中，完全缓解（CR）2例，部分缓解（PR）1例，稳定（SD）22例，进展（PD）19例，有效率（RR）为31．66％，疾病控制率（DC）为68．33％，无疾病进展时间（PFS）为3．2个月（95％ CI 为2．6～5．6个月），总生存时间（OS）为15．2个月（95％ CI 为10．4～22．7个月）。未出现严重不良反应。结论替吉奥胶囊单药口服化疗近期疗效高，不良反应轻，可推荐位一线治疗老年晚期胃癌。
목적：탐토체길오효낭（S-1）치료노년만기위암적유효성화불량반응。방법선택재신강의과대학부속종류의원접수치료적경병리증실적60례노년만기위암병인，급여국산체길오효낭단약구복화료。결과60례환자중，완전완해（CR）2례，부분완해（PR）1례，은정（SD）22례，진전（PD）19례，유효솔（RR）위31．66％，질병공제솔（DC）위68．33％，무질병진전시간（PFS）위3．2개월（95％ CI 위2．6～5．6개월），총생존시간（OS）위15．2개월（95％ CI 위10．4～22．7개월）。미출현엄중불량반응。결론체길오효낭단약구복화료근기료효고，불량반응경，가추천위일선치료노년만기위암。
Objective Using S-1 to treat elderly patients with advanced gastric cancer and research its effica-cy and tolerability.Method For this study 60 patients were enrolled who were pathologically diagnosed as gastric cancer.And they were given S-1 drug for chemotherapy.Result In our study the CR were 2,PR 2,SD 22,PD 19,RR 31.66,DC 68.33%,and the tolerability is high.Conclusion S-1 used as a first-line drug for advanced gastric cancer can improve efficacy with less adverse reactions,and can be a first-line regimen for elderly advanced gastric cancer.