现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
JOURNAL OF MODERN LABORATORY MEDICINE
2014年
5期
149-151
,共3页
巨幼细胞性贫血%叶酸%维生素B1 2
巨幼細胞性貧血%葉痠%維生素B1 2
거유세포성빈혈%협산%유생소B1 2
gigantic young cell anemia%folic acid%vitamin B1 2
目的：探讨血清叶酸（FOL）和维生素 B12（Vit B12）水平在巨幼细胞性贫血（MA）诊疗中的作用。方法选取2010年3月～2013年3月，经检查有明确细胞形态学诊断的巨幼细胞性贫血患者50例作为观察组；另选取同期来院进行体检的52例健康人群作为对照组，观察组接受FOL和Vit B12治疗8～15天，用西门子SIEMENS ADVIA Centaur CP全自动化学发光免疫分析仪对观察组治疗前、治疗后及对照组分别进行血清 FOL和 Vit B12水平检测，对所有检测结果进行统计分析。结果观察组治疗前血清 FOL和 Vit B12水平（2.23±0.11 ng/ml和125.21±94.14 pg/ml）明显低于对照组（5.49±3.91 ng/ml和356.77±185.46 pg/ml），差异均有统计学显著性意义（t＝5.89，P＜0.01；t＝7.90，P＜0.01）；观察组治疗后的血清 FOL和 Vit B12水平（4.26±1.83 ng/ml和307.43±139.81 pg/ml）明显高于治疗前（2.23±0.11 ng/ml和125.21±94.14 pg/ml），差异均有统计学显著性意义（t＝7.83，P＜0.01；t＝7.52，P＜0.01）；观察组治疗后的血清FOL和 Vit B12水平（4.26±1.83 ng/ml和307.43±139.81 pg/ml）与对照组（5.49±3.91 ng/ml和356.77±185.46 pg/ml）比较，差异无统计学意义（t＝1.78，P＞0.05；t＝1.51，P＞0.05）。结论血清 FOL和 Vit B12水平检测，可作为巨幼细胞性贫血诊断和治疗效果监测的有效手段。
目的：探討血清葉痠（FOL）和維生素 B12（Vit B12）水平在巨幼細胞性貧血（MA）診療中的作用。方法選取2010年3月～2013年3月，經檢查有明確細胞形態學診斷的巨幼細胞性貧血患者50例作為觀察組；另選取同期來院進行體檢的52例健康人群作為對照組，觀察組接受FOL和Vit B12治療8～15天，用西門子SIEMENS ADVIA Centaur CP全自動化學髮光免疫分析儀對觀察組治療前、治療後及對照組分彆進行血清 FOL和 Vit B12水平檢測，對所有檢測結果進行統計分析。結果觀察組治療前血清 FOL和 Vit B12水平（2.23±0.11 ng/ml和125.21±94.14 pg/ml）明顯低于對照組（5.49±3.91 ng/ml和356.77±185.46 pg/ml），差異均有統計學顯著性意義（t＝5.89，P＜0.01；t＝7.90，P＜0.01）；觀察組治療後的血清 FOL和 Vit B12水平（4.26±1.83 ng/ml和307.43±139.81 pg/ml）明顯高于治療前（2.23±0.11 ng/ml和125.21±94.14 pg/ml），差異均有統計學顯著性意義（t＝7.83，P＜0.01；t＝7.52，P＜0.01）；觀察組治療後的血清FOL和 Vit B12水平（4.26±1.83 ng/ml和307.43±139.81 pg/ml）與對照組（5.49±3.91 ng/ml和356.77±185.46 pg/ml）比較，差異無統計學意義（t＝1.78，P＞0.05；t＝1.51，P＞0.05）。結論血清 FOL和 Vit B12水平檢測，可作為巨幼細胞性貧血診斷和治療效果鑑測的有效手段。
목적：탐토혈청협산（FOL）화유생소 B12（Vit B12）수평재거유세포성빈혈（MA）진료중적작용。방법선취2010년3월～2013년3월，경검사유명학세포형태학진단적거유세포성빈혈환자50례작위관찰조；령선취동기래원진행체검적52례건강인군작위대조조，관찰조접수FOL화Vit B12치료8～15천，용서문자SIEMENS ADVIA Centaur CP전자동화학발광면역분석의대관찰조치료전、치료후급대조조분별진행혈청 FOL화 Vit B12수평검측，대소유검측결과진행통계분석。결과관찰조치료전혈청 FOL화 Vit B12수평（2.23±0.11 ng/ml화125.21±94.14 pg/ml）명현저우대조조（5.49±3.91 ng/ml화356.77±185.46 pg/ml），차이균유통계학현저성의의（t＝5.89，P＜0.01；t＝7.90，P＜0.01）；관찰조치료후적혈청 FOL화 Vit B12수평（4.26±1.83 ng/ml화307.43±139.81 pg/ml）명현고우치료전（2.23±0.11 ng/ml화125.21±94.14 pg/ml），차이균유통계학현저성의의（t＝7.83，P＜0.01；t＝7.52，P＜0.01）；관찰조치료후적혈청FOL화 Vit B12수평（4.26±1.83 ng/ml화307.43±139.81 pg/ml）여대조조（5.49±3.91 ng/ml화356.77±185.46 pg/ml）비교，차이무통계학의의（t＝1.78，P＞0.05；t＝1.51，P＞0.05）。결론혈청 FOL화 Vit B12수평검측，가작위거유세포성빈혈진단화치료효과감측적유효수단。
Objective To explore the serum folic acid (FOL)and vitamin B12 (Vit B12)levels in gigantic young cell anemia (MA)in the diagnosis and treatment effect.Methods Select in March 2010 to March 2013,examined with clear cell mor-phology in the diagnosis of 50 patients with gigantic young cell anemia as observation group.Another selection during the same period to hospital for a medical 52 cases of healthy people as control group,observation group treated with FOL and Vit B1 2 8~1 5 d,with SIEMENS SIEMENS ADVIA Centaur CP automatic chemiluminescence immune analyzer to observe group before and after treatment and the control group was used to detect the serum FOL and Vit B1 2 levels,respectively, for all the test results were analyzed.Results Observation group before treatment serum FOL and Vit B12 levels (2.23± 0.11 ng/ml and 125.21±94.14 pg/ml)significantly lower than the control group (5.49± 3.91 ng/ml and 356.70±185.46 pg/ml),differences were statistically significant (t=5.89,P<0.01;t=7.90,P<0.01).Observation group after treatment serum FOL and Vit B12 levels (4.26±1.83 ng/ml and 307.43±139.81 pg/ml)were significantly higher than those before treatment (2.23±0.11 ng/ml and 125.21±94.14 pg/ml),differences were statistically significant (t=7.83,P<0.01;t=7.52,P<0.01).Observation group after treatment serum FOL and Vit B12 levels (4.26 ± 1.83 ng/ml and 307.43 ± 139.81 pg/ml)and control group (5.49±3.91 ng/ml and 356.70±185.46 pg/ml),there was no statistically significant difference (t=1.78,P>0.05;t=1.51,P>0.05).Conclusion The detection of serum FOL and Vit B12 levels,can be used as a gigantic young cell anemia is the effective means to the diagnosis and treatment effect monitoring.
