CAJ | 학술논문

目的：调查武汉地区泌尿道感染病原菌的分布及耐药情况，为诊断和治疗泌尿道感染提供可靠依据。方法对2012年1月1日～2014年6月30日武汉大学人民医院泌尿道感染患者尿培养分离出的5378株病原菌的分布及耐药性进行回顾性分析，使用BD Pheonix-100进行细菌的鉴定及药敏，真菌使用显色平板进行分离鉴定。结果泌尿系感染患者尿液培养分离出病原菌5378株，共104种，其中革兰阴性菌2945株，占54.8％，以大肠埃希菌为主；革兰阳性菌1657株，占30.8％，以肠球菌属为主；真菌776株，占14.4％。主要分离菌对抗生素的耐药情况不同：大肠埃希菌对青霉素的耐药率最高，均＞83％，未发现碳青霉烯类耐药菌株；发现对万古霉素和利奈唑胺耐药的肠球菌，耐药率均在0.3％以上；MRCNS的检出率＞83％。结论泌尿系感染病原菌中以大肠埃希菌最常见。β-内酰胺酶抑制剂复合制剂可作为大肠埃希菌感染的经验性用药；MRCNS检出率增高，应引起密切关注。
목적：조사무한지구비뇨도감염병원균적분포급내약정황，위진단화치료비뇨도감염제공가고의거。방법대2012년1월1일～2014년6월30일무한대학인민의원비뇨도감염환자뇨배양분리출적5378주병원균적분포급내약성진행회고성분석，사용BD Pheonix-100진행세균적감정급약민，진균사용현색평판진행분리감정。결과비뇨계감염환자뇨액배양분리출병원균5378주，공104충，기중혁란음성균2945주，점54.8％，이대장애희균위주；혁란양성균1657주，점30.8％，이장구균속위주；진균776주，점14.4％。주요분리균대항생소적내약정황불동：대장애희균대청매소적내약솔최고，균＞83％，미발현탄청매희류내약균주；발현대만고매소화리내서알내약적장구균，내약솔균재0.3％이상；MRCNS적검출솔＞83％。결론비뇨계감염병원균중이대장애희균최상견。β-내선알매억제제복합제제가작위대장애희균감염적경험성용약；MRCNS검출솔증고，응인기밀절관주。
Objective To investigate the tendency of distribution and drug-resistance of the causative organisms of urinary tract infections(UTIs)in Wuhan,and provide reliable evidence for clinical treatment.Methods Analyzed the 5 378 stains of pathogen isolated from the urine of patients in hospital.The bacteria isolates were identified with BD Phoenix-100 while can-dida isolates were identified by color plate.Results A total of 5 378 stains of pathogen had been isolated.There were 2 945 stains (54.8%)of Gram-negative bacteria,1 657 stains (30.8%)of Gram-positive bacteria,776 stains (14.4%)of fungus. The rates of Escherichiacoli resistant to penicillin were highest (>83%),and there were no carbapenem-resistant strains. There were vancomycin and linezolid-resistant Enterococcispp strains,the lowest dection rates of which were 0.3%.The de-tection rate of MRCNS was over 83%.Conclusion Escherichiacoli was the most common pathogens of urinary tract infec-tion,and theβ-lactamase inhibitor complex can be used as empirical treatment of E.coli infections.Thedetection rate of MRCNS increased,which shoud be kept a watchful eye on.