CAJ | 학술논문

有氧运动具有明确的血管新生效应，包括缺血心脏，但其机制尚未完全阐明。心肌梗死（ MI）后冠脉微血管新生是心脏修复的前提。新近研究表明，血管新生来源于体内干/祖细胞的动员与参与，并以旁分泌效应影响内皮细胞（ EC）功能及微血管分布效果，运动可以动员、激活内源性干细胞因子和血管生成因子的表达与分泌，并能从表观遗传学角度影响心脏血管新生。探索不同运动方式及强度对缺血心脏血管新生的作用及其分子机制，对缺血心脏的预防及术后康复具有重要意义。本文从心脏血管新生及其调控机制、自体干细胞动员参与缺血心脏的血管新生和运动通过干细胞动员促进缺血心脏血管新生等方面综述运动促进缺血心脏血管新生的主要机制、存在问题及相关研究进展。
유양운동구유명학적혈관신생효응，포괄결혈심장，단기궤제상미완전천명。심기경사（ MI）후관맥미혈관신생시심장수복적전제。신근연구표명，혈관신생래원우체내간/조세포적동원여삼여，병이방분비효응영향내피세포（ EC）공능급미혈관분포효과，운동가이동원、격활내원성간세포인자화혈관생성인자적표체여분비，병능종표관유전학각도영향심장혈관신생。탐색불동운동방식급강도대결혈심장혈관신생적작용급기분자궤제，대결혈심장적예방급술후강복구유중요의의。본문종심장혈관신생급기조공궤제、자체간세포동원삼여결혈심장적혈관신생화운동통과간세포동원촉진결혈심장혈관신생등방면종술운동촉진결혈심장혈관신생적주요궤제、존재문제급상관연구진전。
Aerobic exercise has specific angiogenesis effect, also in the ischemic heart.But its mecha-nism has not been fully clarified.Coronary microvascular angiogenesis is the precondition of heart repair after myocardial infarction ( MI) .Recent studies have shown that angiogenesis is caused by endogenous stem cell /progenitor mobilization and participation, and its paracrine effects on endothelial cells ( EC) function and microvascular distribution.Exercise could mobilize and activate the expression and secretion of endogenous stem cell and angiogenic factors, and affect the cardiac angiogenesis in epigenetics.Inves-tigating the effect of different exercise methods and intension on ischemic cardiac angiogenesis and its mo-lecular mechanism are of great significance on prevention and postoperative rehabilitation of MI.This re-view summarized the main mechanism, existing problems and related research progress on exercise impro-ving ischemic cardiac angiogenesis through cardiac angiogenesis and its regulation mechanisms, endoge-nous stem cell mobilization and participates in angiogenesis of ischemic heart, and exercise improving is-chemic cardiac angiogenesis through stem cell mobilization.