CAJ | 학술논문

目的：研究菲牛蛭提取物联合顺铂治疗 S180荷瘤鼠效果及其减毒作用。方法：建立 S180荷瘤鼠模型10天后，将40只 BALB ／c 小鼠按肿瘤体积随机分为阴性对照组、顺铂组、菲牛蛭提取物组、菲牛蛭提取物＋顺铂组。分组后开始给药，连续给药7天，第8天处死各组小鼠，取血清检测肝肾功能指标；取肾脏进行组织病理学检查；剥离肿瘤称重计算抑瘤率。结果：菲牛蛭提取物与顺铂联合使用具有抑制肿瘤生长的作用（P ＜0.05）。与顺铂组比较，联合用药后菲牛蛭提取物可使 S180荷瘤鼠的 ALT、AST、TBIL、BUN、CREA 含量降低（P ＜0.05）。结论：菲牛蛭提取物与顺铂联合使用治疗 S180荷瘤鼠具有相加作用，同时菲牛蛭提取物可减轻顺铂引起的肝肾毒性。
목적：연구비우질제취물연합순박치료 S180하류서효과급기감독작용。방법：건립 S180하류서모형10천후，장40지 BALB ／c 소서안종류체적수궤분위음성대조조、순박조、비우질제취물조、비우질제취물＋순박조。분조후개시급약，련속급약7천，제8천처사각조소서，취혈청검측간신공능지표；취신장진행조직병이학검사；박리종류칭중계산억류솔。결과：비우질제취물여순박연합사용구유억제종류생장적작용（P ＜0.05）。여순박조비교，연합용약후비우질제취물가사 S180하류서적 ALT、AST、TBIL、BUN、CREA 함량강저（P ＜0.05）。결론：비우질제취물여순박연합사용치료 S180하류서구유상가작용，동시비우질제취물가감경순박인기적간신독성。
Objective Manillensis extract combined with cisplatin in the treatment of mice bearing S180 tumor and attenuation effects.Method S180 tumor -bearing mice model for 10 days,fourty BALB/c mice were randomly divided into negative tumor volume in the control group,cisplatin,manillensis extract group,manillensis extract +cisplatin group.After the group began to administra-tion,continuous.administration for 7 days,10 mice in each group were sacrificed on eighth day,the serum to detect indicators of liver and kidney function;taken for histopathological examination of kidney;peel the tumor weighed to calculate the inhibition rate.Results Manillensis extract in combination with cisplatin inhibited tumor growth (P <0.05).compared with cisplatin,the combination thera-py can extract manillensis ALT S180 tumor -bearing mice,AST,TBIL,BUN,CREA was decreased (P <0.05).Conclusion Ma-nillensis extract used in combination therapy with cisplatin S180 tumor -bearing mice have an additive effect,while manillensis extract kidney toxicant reduce cisplatin -induced.