CAJ | 학술논문

目的：探讨心脏型脂肪酸结合蛋白在早期急性心肌梗死中的诊断价值。方法收集因“胸痛、胸闷3 h 以内”就诊，拟诊为急性心肌梗死患者186例，检测所有入选者的血浆肌酸磷酸激酶同工酶（CK-MB）、肌钙蛋白-I（CTn-I）和心脏型脂肪酸结合蛋白（H-FABP）。比较3种指标对早期急性心肌梗死诊断的敏感性和特异性。结果与非心肌梗死组和对照组相比，急性心肌梗死组患者血浆 CK-MB、CTn-I 及 H-FABP 明显升高（P ＜0．05）；与 CK-MB 和 CTn-I 相比，H-FABP 对3 h 以内的急性心肌梗死诊断的敏感性较高，而特异性则低于 CTn-I，但高于 CK-MB。结论对于发病3 h 内的急性心肌梗死患者，检测 H-FABP 可以在一定程度上提高对早期急性心肌梗死的诊断率。
목적：탐토심장형지방산결합단백재조기급성심기경사중적진단개치。방법수집인“흉통、흉민3 h 이내”취진，의진위급성심기경사환자186례，검측소유입선자적혈장기산린산격매동공매（CK-MB）、기개단백-I（CTn-I）화심장형지방산결합단백（H-FABP）。비교3충지표대조기급성심기경사진단적민감성화특이성。결과여비심기경사조화대조조상비，급성심기경사조환자혈장 CK-MB、CTn-I 급 H-FABP 명현승고（P ＜0．05）；여 CK-MB 화 CTn-I 상비，H-FABP 대3 h 이내적급성심기경사진단적민감성교고，이특이성칙저우 CTn-I，단고우 CK-MB。결론대우발병3 h 내적급성심기경사환자，검측 H-FABP 가이재일정정도상제고대조기급성심기경사적진단솔。
Objective To investigate the value of heart-type fatty acid-binding protein in the diagnosis of early myocardial infarc-tion.Methods In 186 cases of suspected acute myocardial infarction due to "chest pain,chest tightness" for 3 h,plasma CK-MB, troponin-I(CTn-I)and heart-type fatty acid-binding protein(H-FABP)were detected.The sensitivity and specificity in diagnosing early myocardial infarction were compared among 3 kinds of indexes.Results Compared with the non-infarction group and the con-trol group,plasma CK-MB,CTn-I and H-FABP in the acute myocardial infarction group were significantly increased (P <0.05 );compared with CK-MB and CTn-I,the sensitivity of H-FABP to the diagnosis of acute myocardial infarction within 3 h was higher, but its specificity was lower than that of CTn-I and higher than that of CK-MB.Conclusion For the patients with acute myocardial infarction within 3 h after onset,detecting H-FABP can increase the diagnostic rate of early myocardial infarction to a certain extent.