CAJ | 학술논문

目的：探讨血小板最大聚集率（MAR）、血小板计数（PLT）、血小板比容（PCT）、血小板分布宽度（PDW）、血小板平均体积（MPV）与急性脑梗死病程的关系，为其临床早期诊断和治疗提供依据。方法选取该院107例急性脑梗死（ACI）患者，根据头部 CT 或 MRI 病灶大小，梗死体积按 Pullicino 公式（长×宽×层数/2）计算进行分组：大梗死组（病灶体积大于10 cm3）、中梗死组（病灶体积4～10 cm3）和小梗死组（病灶体积小于4 cm3），40例健康对照组，分别用 PL-11血小板分析仪检测经 PLR-06血小板诱聚剂诱导前后的 MAR、PLT、PDW、MPV、PCT，对测定结果进行统计分析。结果（1）与对照组比较，经 PLR-06血小板诱聚剂诱导前，大脑梗死组 PLT、PCT、PDW、MPV 明显升高（P ＜0．01）；中、小脑梗死组 PLT、PCT、PDW、MPV 升高（P ＜0．05）。（2）与对照组比较，经 PLR-06血小板诱聚剂诱导后，各脑梗死组 MAR 升高（P ＜0．05）；PLT 差异无统计学意义（P ＞0．05）；大、中脑梗死组 PCT、PDW、MPV 升高（P ＜0．05）；小脑梗死组 PCT、PDW、MPV 差异无统计学意义（P ＞0．05）。结论血小板聚集率、数量及体积的改变与急性脑梗死的发生和发展密切相关，监测它们的变化对预防和治疗急性脑梗死具有重要的临床意义。
목적：탐토혈소판최대취집솔（MAR）、혈소판계수（PLT）、혈소판비용（PCT）、혈소판분포관도（PDW）、혈소판평균체적（MPV）여급성뇌경사병정적관계，위기림상조기진단화치료제공의거。방법선취해원107례급성뇌경사（ACI）환자，근거두부 CT 혹 MRI 병조대소，경사체적안 Pullicino 공식（장×관×층수/2）계산진행분조：대경사조（병조체적대우10 cm3）、중경사조（병조체적4～10 cm3）화소경사조（병조체적소우4 cm3），40례건강대조조，분별용 PL-11혈소판분석의검측경 PLR-06혈소판유취제유도전후적 MAR、PLT、PDW、MPV、PCT，대측정결과진행통계분석。결과（1）여대조조비교，경 PLR-06혈소판유취제유도전，대뇌경사조 PLT、PCT、PDW、MPV 명현승고（P ＜0．01）；중、소뇌경사조 PLT、PCT、PDW、MPV 승고（P ＜0．05）。（2）여대조조비교，경 PLR-06혈소판유취제유도후，각뇌경사조 MAR 승고（P ＜0．05）；PLT 차이무통계학의의（P ＞0．05）；대、중뇌경사조 PCT、PDW、MPV 승고（P ＜0．05）；소뇌경사조 PCT、PDW、MPV 차이무통계학의의（P ＞0．05）。결론혈소판취집솔、수량급체적적개변여급성뇌경사적발생화발전밀절상관，감측타문적변화대예방화치료급성뇌경사구유중요적림상의의。
Objective To investigate the relationship between platelet maximum aggregation rate(MAR),platelet thrombocyt-ocrit(PCT),platelet count(PLT),platelet distribution width(PDW)and mean platelet volume(MPV)with the course of acute cere-bral infarction(ACI)to provide the basis for its clinical early diagnosis and treatment.Methods 107 patients with ACI in our hospi-tal were selected and divided into the great infarction group(infarction size >10 cm3 ),middle infarction group(infarction size 4-10 cm3 )and small infarction group(infarction size<4 cm3 )according to the infarction lesion size by head CT or MRI and the infarction volume calculated by the Pullicino formula(length×width×layer number/2),40 healthy individuals were selected as the healthy control group.MAR,PLT,PDW,MPV and PCT were detected before and after the induction by PLR-06.Results (1 )Compared with the control group,PLT,PCT,PDW and MPV before the induction by PLR-06 in the great infarction group were obviously in-creased(P <0.01);PLT,PCT,PDW and MPV in the middle and small infarction groups were increased(P <0.05).(2)Compared with the control group,MAR after the induction by PLR-06 in each infarction group was increased(P <0.05);PLT had no statisti-cal difference among the groups(P >0.05 );PCT,PDW and MPV in the great and middle infarction groups were increased(P <0.05);PCT,PDW and MPV in the small infarction group had no statistical differences(P >0.05).Conclusion The change of the platelet aggregation rate,number and volume is closely related with the occurrence and development of ACI,monitoring their change has important clinical significance to prevention and treat ACI.