CAJ | 학술논문

目的：分析和监测该院产超广谱β-内酰胺酶（ESBLs）大肠埃希菌（E．Coli）感染分布及对常用抗菌药物的耐药性。方法连续观察2008～2011年本院 E．Coli 培养的药敏结果并对结果进行汇总及描述性分析。结果4年产 ESBLs E．Coli 检出率均大于50％；产 ESBLs Coli 以咽拭子标本产生率最高。产 ESBLs 菌株耐药性大多高于非产 ESBLs 株（P ＜0．05），产 ESBLs E．Coli 呈多药耐药现象，但产 ESBLs E．Coli 对一些抗菌药物耐药率有逐年降低的趋势。结论产 ESBLs E．Coli 耐药情况严重，对已发现的对碳青霉烯类耐药的产 ESBLs E．Coli 应引起关注，可用耐药率逐渐降低的抗菌药物替换治疗耐药率增高的药物，加强细菌耐药监测可以及时发现临床分离细菌耐药性变化的趋势，为临床经验用药提供参考。
목적：분석화감측해원산초엄보β-내선알매（ESBLs）대장애희균（E．Coli）감염분포급대상용항균약물적내약성。방법련속관찰2008～2011년본원 E．Coli 배양적약민결과병대결과진행회총급묘술성분석。결과4년산 ESBLs E．Coli 검출솔균대우50％；산 ESBLs Coli 이인식자표본산생솔최고。산 ESBLs 균주내약성대다고우비산 ESBLs 주（P ＜0．05），산 ESBLs E．Coli 정다약내약현상，단산 ESBLs E．Coli 대일사항균약물내약솔유축년강저적추세。결론산 ESBLs E．Coli 내약정황엄중，대이발현적대탄청매희류내약적산 ESBLs E．Coli 응인기관주，가용내약솔축점강저적항균약물체환치료내약솔증고적약물，가강세균내약감측가이급시발현림상분리세균내약성변화적추세，위림상경험용약제공삼고。
Objective To analyze and monitor the distribution of EBSLs-producing E.coli in our hospital and its resistance to commonly used antibacterial drugs.Methods The drug sensitivity test results of E.coli cultured in our hospital from 2008 to 2011 were continuously observed and performed the summary and the descriptive analysis.Results The detection rate of EBSLs-produ-cing E.coli during these 4 years was more than 50%.The generation rate of ESBLs-producing E.coli from the pharyngeal swab samples was the highest.The drug resistance of EBSLs-producing E.coli was mostly higher than that of non-EBSLs-producing E. coli,the difference was statistically significant(P <0.05).EBSLs-producing E.Coli showed the multi-drug resistant phenomenon. But the resistance rate of EBSLs-producing E.Coli to some antimicrobial drugs had the decreasing tendency year by year.Conclusion The drug-resistance situation of ESBLs-producing E.Coli is serious.The diceovered carbapenems-resistance ESBLs-producing E. Coli should cause the concern.The antibacterial drugs with increased drug-resistance rate should be replaced by the antibacterial drugs with the gradually decreased drug resistance rate.Strengthening the bacterial drug resistance minitoring can timely discover the change trend of clinically isolated bacteria and has the improtant significance to provide reference for clinically empirical medica-tion.