国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
13期
1734-1735,1750
,共3页
黄燕新%姜朝新%冼洁能%晏文芬
黃燕新%薑朝新%冼潔能%晏文芬
황연신%강조신%승길능%안문분
降钙素原%血流感染%诊断
降鈣素原%血流感染%診斷
강개소원%혈류감염%진단
procalcitonin%bloodstream infection%diagnosis
目的:探讨血清降钙素原(PCT)定量检测在儿科血流感染诊断中的价值。方法回顾性分析某院183例同时送检血液培养和 PCT 检测的结果,以血培养为金标准,把患者分为非血流感染组和血流感染组,比较两组间血清 PCT 浓度的差异。两组间 PCT 值差异比较采用 Mann-WhitneyU 检验,P <0.05为差异有统计学意义。结果非血流感染组血清 PCT 浓度为0.15(0.065~0.55)ng/mL,血流感染组血清 PCT 水平为1.11(0.505~8.975)ng/mL,两组间的血清 PCT 浓度差异有统计学意义(P =0.000);以0.50 ng/mL 为界点,PCT 诊断的灵敏度为77.8%、特异度为73.3%,阳性预测值和阴性预测值分别为24.1%和96.8%。结论定量检测 PCT 可辅助快速排除或诊断血流感染,为避免抗菌药物的过度使用或早期抗感染治疗提供参考。
目的:探討血清降鈣素原(PCT)定量檢測在兒科血流感染診斷中的價值。方法迴顧性分析某院183例同時送檢血液培養和 PCT 檢測的結果,以血培養為金標準,把患者分為非血流感染組和血流感染組,比較兩組間血清 PCT 濃度的差異。兩組間 PCT 值差異比較採用 Mann-WhitneyU 檢驗,P <0.05為差異有統計學意義。結果非血流感染組血清 PCT 濃度為0.15(0.065~0.55)ng/mL,血流感染組血清 PCT 水平為1.11(0.505~8.975)ng/mL,兩組間的血清 PCT 濃度差異有統計學意義(P =0.000);以0.50 ng/mL 為界點,PCT 診斷的靈敏度為77.8%、特異度為73.3%,暘性預測值和陰性預測值分彆為24.1%和96.8%。結論定量檢測 PCT 可輔助快速排除或診斷血流感染,為避免抗菌藥物的過度使用或早期抗感染治療提供參攷。
목적:탐토혈청강개소원(PCT)정량검측재인과혈류감염진단중적개치。방법회고성분석모원183례동시송검혈액배양화 PCT 검측적결과,이혈배양위금표준,파환자분위비혈류감염조화혈류감염조,비교량조간혈청 PCT 농도적차이。량조간 PCT 치차이비교채용 Mann-WhitneyU 검험,P <0.05위차이유통계학의의。결과비혈류감염조혈청 PCT 농도위0.15(0.065~0.55)ng/mL,혈류감염조혈청 PCT 수평위1.11(0.505~8.975)ng/mL,량조간적혈청 PCT 농도차이유통계학의의(P =0.000);이0.50 ng/mL 위계점,PCT 진단적령민도위77.8%、특이도위73.3%,양성예측치화음성예측치분별위24.1%화96.8%。결론정량검측 PCT 가보조쾌속배제혹진단혈류감염,위피면항균약물적과도사용혹조기항감염치료제공삼고。
Objective To explore the application value of serum procalcitonin(PCT)quantitative detection in diagnosing pediat-ric bloodstream infection.Methods The results of 183 cases of blood culture and simultaneous PCT detection in a hospital from February to November 2013 were analyzed retrospectively.The patients were divided into the non-bloodstream infection group and the bloodstream infection group according to the blood culture results as the golden standard.The differences of serum PCT concen-tration were compared between the two groups by the Mann-Whitney U test.Results The serum PCT concentration was 0.15 (0.065-0.55)ng/mL in the non-bloodstream infection group and 1.11(0.505-8.975)ng/mL in the bloodstream infection group, the difference was statistically significant(P =0.000);with 0.50ng/mL as the cut-off value of diagnosis,the sensitivity and the spe-cificity of PCT was 77.8% and 73.3% respectively,the positive and pegative predictive value of PCT was 24.1% and 96.8% re-spectively.Conclusion The quantitative detection of PCT can assist in rapidly diagnosing or excluding bloodstream infection and provides reference for avoiding the overuse of antibiotics or conducting the early anti-infection therapy.