CAJ | 학술논문

目的：探讨组织工程支架材料在脊髓损伤( SCI)修复中的应用进展。方法在中国生物医学文献数据库( CBM)、PubMed数据库、Ovid Medline数据库查阅国内外有关应用组织工程支架修复SCI的相关文献，进行归纳总结。结果用于脊髓再生的生物工程组织支架的材料包括天然材料、合成材料和复合材料。天然材料包括透明质酸、藻酸盐、胶原、琼脂糖等，合成材料包括聚乳酸、聚乙醇酸及其聚合物等，以及二者相结合的复合材料。生物支架制作技术分为常规技术、静电纺丝技术和无固相成形技术3种：常规技术的作用非常有限；静电纺丝技术是使用最普遍的技术，但尚待完善；无固相成形技术是较新的技术，并具有更大的发展潜力。支架的治疗策略分为电刺激增强支架中生物细胞的活性，模拟细胞外基质的多肽修饰支架，引入生物活性分子和活性细胞的支架，延迟植入支架。克服SCI后恶劣的内环境，合理使用各种支架的治疗策略更加有利于发挥支架的治疗作用。结论组织工程支架在SCI的应用中可对轴突修复提供物理性的桥接，能够促进再生轴突的生长、连接和进一步恢复神经功能。
목적：탐토조직공정지가재료재척수손상( SCI)수복중적응용진전。방법재중국생물의학문헌수거고( CBM)、PubMed수거고、Ovid Medline수거고사열국내외유관응용조직공정지가수복SCI적상관문헌，진행귀납총결。결과용우척수재생적생물공정조직지가적재료포괄천연재료、합성재료화복합재료。천연재료포괄투명질산、조산염、효원、경지당등，합성재료포괄취유산、취을순산급기취합물등，이급이자상결합적복합재료。생물지가제작기술분위상규기술、정전방사기술화무고상성형기술3충：상규기술적작용비상유한；정전방사기술시사용최보편적기술，단상대완선；무고상성형기술시교신적기술，병구유경대적발전잠력。지가적치료책략분위전자격증강지가중생물세포적활성，모의세포외기질적다태수식지가，인입생물활성분자화활성세포적지가，연지식입지가。극복SCI후악렬적내배경，합리사용각충지가적치료책략경가유리우발휘지가적치료작용。결론조직공정지가재SCI적응용중가대축돌수복제공물이성적교접，능구촉진재생축돌적생장、련접화진일보회복신경공능。
Objective To explore the progress of tissue engineering scaffold materials for the repair of spinal cord injury( SCI) . Methods To review and summarize tissue engineering scaffold materials for the repair of SCI at domestic and abroad in PubMed database, CBM database and Ovid Medline database. Results Tissue engineering scaffold materials for the repair of SCI involve natural materials ( hyaluronic acid, alginate, collagen, and agarose et al ) , synthetic materials [ Poly lactic acid, poly glycolic acid (PGA), and their copolymers (PLGA) et al] and composite materials. Fabrication of scaffolds involve conventional methods, electrospinning textile technologie and solid free-form fabricatio. The utility of conventional techniques is limited. Electrospinning textile technologies is a popular method for scaffold fabrication. The solid free-form fabricatio has recently attracted increasing attention. Current therapeutic strategies with scaffolds involves electrical stimulation, modification of scaffolds to mimic the ECM, incorporation of bioactive molecules and living cells and delayed implantation of scaffolds. Overcoming the hostile environment will enhance axon regrowth after SCI. Conclusions Artificial tissue repair scaffolds may provide a physical guide to allow regenerative axon growth that bridges the lesion cavity and restores functional neural connectivity.