中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
9期
1236-1237
,共2页
免疫调节剂%术后感染%甘露聚糖肽注射液
免疫調節劑%術後感染%甘露聚糖肽註射液
면역조절제%술후감염%감로취당태주사액
Immunomodulator%Postoperative Infection%Mannatide Injections
目的：评价甘露聚糖肽注射液在手术患者术后感染的临床价值。方法：回顾性分析术后患者采用甘露聚糖肽注射液治疗的病案，根据入选和排除标准纳入98例术后患者为治疗组；抽取采用了相同手术患者98例，作为对照组。评价两组术后的感染情况，住院情况，伤口愈合情况，抗生素使用情况，并对血清免疫细胞水平评价。结果：免疫调节剂治疗组的总感染率、呼吸道感染率、切口感染率均低于对照组，分别为11.8% vs 33.6%、7.1% vs 16.3%、3.1% vs 15.3%。泌尿系统感染率无差异(2.0% vs 2.0%)。免疫调节剂治疗组平均住院时间及抗生素使用时间均短于对照组，分别为6.5d vs 8.2d、4.1d vs 5.2d。另外免疫调剂组甲级愈合远高于空白组。免疫细胞检测显示，免疫调节组CD4+，NK细胞水平均高于对照组。结论：甘露聚糖肽可明确降低术后感染，促进伤口愈合，缩短病程。其机制可能与其激活机体免疫有关。
目的：評價甘露聚糖肽註射液在手術患者術後感染的臨床價值。方法：迴顧性分析術後患者採用甘露聚糖肽註射液治療的病案，根據入選和排除標準納入98例術後患者為治療組；抽取採用瞭相同手術患者98例，作為對照組。評價兩組術後的感染情況，住院情況，傷口愈閤情況，抗生素使用情況，併對血清免疫細胞水平評價。結果：免疫調節劑治療組的總感染率、呼吸道感染率、切口感染率均低于對照組，分彆為11.8% vs 33.6%、7.1% vs 16.3%、3.1% vs 15.3%。泌尿繫統感染率無差異(2.0% vs 2.0%)。免疫調節劑治療組平均住院時間及抗生素使用時間均短于對照組，分彆為6.5d vs 8.2d、4.1d vs 5.2d。另外免疫調劑組甲級愈閤遠高于空白組。免疫細胞檢測顯示，免疫調節組CD4+，NK細胞水平均高于對照組。結論：甘露聚糖肽可明確降低術後感染，促進傷口愈閤，縮短病程。其機製可能與其激活機體免疫有關。
목적：평개감로취당태주사액재수술환자술후감염적림상개치。방법：회고성분석술후환자채용감로취당태주사액치료적병안，근거입선화배제표준납입98례술후환자위치료조；추취채용료상동수술환자98례，작위대조조。평개량조술후적감염정황，주원정황，상구유합정황，항생소사용정황，병대혈청면역세포수평평개。결과：면역조절제치료조적총감염솔、호흡도감염솔、절구감염솔균저우대조조，분별위11.8% vs 33.6%、7.1% vs 16.3%、3.1% vs 15.3%。비뇨계통감염솔무차이(2.0% vs 2.0%)。면역조절제치료조평균주원시간급항생소사용시간균단우대조조，분별위6.5d vs 8.2d、4.1d vs 5.2d。령외면역조제조갑급유합원고우공백조。면역세포검측현시，면역조절조CD4+，NK세포수평균고우대조조。결론：감로취당태가명학강저술후감염，촉진상구유합，축단병정。기궤제가능여기격활궤체면역유관。
[ABSTRACT]Objective: To evaluate the clinical efficacy of mannatide injection as an immune-modulator in the treatment of postoperative infection.Methods:According to the inclusion and exclusion standard, 98 postoperative patients were chosen, on whom a retrospective study about mannatide injection was conducted.Other 98 patients after undergoing the same surgeries served as the control group.Postoperative infection,hospitalization,wound healing,using of antibiotics and immunocyte level in serum of both groups were evaluated.Results:The total infection rate (11.8%),respiratory infection rate (7.1%) and wound infection rate (3.1%) of treatment group dosed with immune-modulator were lower than that of the control group (33.6%, 16.3% and 15.3% ).There was no difference in urinary tract infection (1.4% vs 1.4%).The average stay (6.5d),and the time of using antibiotic (4.1d) of the treatment group were both shorter than that of the control group (8.2d and 5.2d) Healing rate of the treatment group was much higher than the control group.Detecting immune cells showed both CD4+,and NK cell levels of immunomodulatory group were higher than the control group.Conclusion:Mannatide could definitely reduce postoperative infection, help wound healing and shorten the course of disease.The mechanism maybe related to activation of immunity.
