CAJ | 학술논문

目的探讨韶关市妊娠期糖尿病(GDM)的发病率、瘦素及脂联素水平及干预变化.方法采取分层整群随机抽样方法对韶关地区2006年1月至2010年12月确诊GDM患者262例及1508例正常孕妇的血清瘦素、脂联素水平进行分析,并比较193例单纯饮食控制及59例应用饮食控制加胰岛素治疗的GDM患者治疗前后瘦素、脂联素及糖化血红蛋白变化情况.结果 GDM组患者的血清瘦素水平明显高于正常组(P＜0.05),而脂联素水平却明显低于正常组(P＜0.05).193例单纯饮食控制的GDM患者治疗后糖化血红蛋白降低,血清瘦素水平降低,血清脂联素水平升高.59例应用饮食控制加胰岛素治疗的GDM患者治疗后糖化血红蛋白明显降低,血清瘦素及血清脂联素水平均升高.结论血清瘦素、脂联素与GDM的发生密切相关,结合两个指标,可以预测GDM的发生,饮食控制加胰岛素治疗可改善GDM患者的预后.
목적 탐토소관시임신기당뇨병(GDM)적발병솔、수소급지련소수평급간예변화.방법 채취분층정군수궤추양방법대소관지구2006년1월지2010년12월학진GDM환자262례급1508례정상잉부적혈청수소、지련소수평진행분석,병비교193례단순음식공제급59례응용음식공제가이도소치료적GDM환자치료전후수소、지련소급당화혈홍단백변화정황.결과 GDM조환자적혈청수소수평명현고우정상조(P＜0.05),이지련소수평각명현저우정상조(P＜0.05).193례단순음식공제적GDM환자치료후당화혈홍단백강저,혈청수소수평강저,혈청지련소수평승고.59례응용음식공제가이도소치료적GDM환자치료후당화혈홍단백명현강저,혈청수소급혈청지련소수평균승고.결론 혈청수소、지련소여GDM적발생밀절상관,결합량개지표,가이예측GDM적발생,음식공제가이도소치료가개선GDM환자적예후.
Objective To investigate the morbidity of gestational diabetes mellitus (GDM) and levels of leptin and adiponectin and changes of intervention in patients with GDM in Shaoguan.Methods Using stratified cluster random sampling method,analyzed the serum levels of leptin and adiponectin in 262 patients with GDM and 1508 healthy pregnant women in Shaoguan from January,2006 to December,2010.Changes of leptin,adiponectin,and glycosylated hemoglobin in 193 GDM patients accepting diet therapy and 59 ones treated with diet therapy and insulin were compared before and after the treatment.Results Serum level of leptin was markedly higher in GDM group than in healthy group (P＜ 0.05),while adiponectin level was significantly lower (P＜ 0.05).Glycosylated hemoglobin and leptin levels became lower,but adiponectin level higher,in 193 GDM patients taking diet therapy; glycosylated level got obviously lower,but levels of leptin and adiponectin higher,in 59 ones treated with diet therapy and insulin.Conclusions Serum leptin and adiponectin closely correlate with the incidence of GDM.Combination detection of these two indicators can predict the occurrence of GDM.Diet therapy in combination with insulin can improve the prognosis of GDM patients.