CAJ | 학술논문

目的：观察分析奥美沙坦联合苯磺酸氨氯地平治疗原发性高血压的临床效果。方法回顾性分析我院在2010年12月至2012年12月收治的118例原发性高血压患者的病历资料，按照是否进行了奥美沙坦的治疗方法将其分为观察组和实验组；观察组患者采用奥美沙坦联合苯磺酸氨氯地平的治疗方法，对照组患者采用单纯苯磺酸氨氯地平的治疗方法；2组分别治疗6周，在此期间观察2组患者出现不良反应等情况，6周之后，对2组患者进行临床疗效的比较。结果观察组治疗后收缩压和舒张压[（140±10）/（86±5）mmHg]与对照组[（142±10）/（88±5）mmHg]相比，差异有统计学意义（P＜0.05）。观察组有64％患者有显著效果，对照组有41％的患者有显著效果，2组差异有统计学意义（P＜0.05）。观察组患者中有4％的患者出现不良反应，对照组有22％的患者出现不良反应，2组差异有统计学意义（P＜0.05）。结论奥美沙坦联合苯磺酸氨氯地平治疗原发性高血压疗效显著且较安全。
목적：관찰분석오미사탄연합분광산안록지평치료원발성고혈압적림상효과。방법회고성분석아원재2010년12월지2012년12월수치적118례원발성고혈압환자적병력자료，안조시부진행료오미사탄적치료방법장기분위관찰조화실험조；관찰조환자채용오미사탄연합분광산안록지평적치료방법，대조조환자채용단순분광산안록지평적치료방법；2조분별치료6주，재차기간관찰2조환자출현불량반응등정황，6주지후，대2조환자진행림상료효적비교。결과관찰조치료후수축압화서장압[（140±10）/（86±5）mmHg]여대조조[（142±10）/（88±5）mmHg]상비，차이유통계학의의（P＜0.05）。관찰조유64％환자유현저효과，대조조유41％적환자유현저효과，2조차이유통계학의의（P＜0.05）。관찰조환자중유4％적환자출현불량반응，대조조유22％적환자출현불량반응，2조차이유통계학의의（P＜0.05）。결론오미사탄연합분광산안록지평치료원발성고혈압료효현저차교안전。
Objective To observe and analyze clinical observation on the curative effect of olmesartan combi-ning with amlodipine besylate tablet on the treatment of primary hypertension .Methods Medical records of 118 cases with primary hypertension that were accepted by a hospital from December ,2010 to December ,2012 are ret-rospectively analyzed .They were equally and randomly divided into observation group of which patients adopt the treatment of olmesartan combining with amlodipine besylate tablet and contrast group ,of which patients adopt the treatment of Amlodipine Besylate Tablet .The treatment lasts 6 weeks .During the treatment ,the condition of ad-verse reactions in the two groups would be observed .After six weeks ,the clinical effect of patients in two groups were compared .Results After treatment ,the comparative results of systolic pressure and diastolic pressure in ob-servation group[ (140 ± 10)/(86 ± 5)mmHg]with contrast group[(142 ± 10)/(88 ± 5)mmHg] showed obviously statistically significant difference ( P <0.05) .Sixty-four percent patients in observation group had obvious effect and 41% cases in contrast group had obvious effect .The two groups showed obvious differences .The result of contrast had a statistical significance ( P <0.05) .About 4% patients in observation group reacted with adverse reactions and 22% cases in contrast group reacted with adverse reactions .The result of contrast had a statistical significance ( P <0.05).Conclusion The effect of olmesartan combining with amlodipine besylate tablet on the treatment of primary hypertension is obvious and safe.