中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
8期
38-39
,共2页
刘楠%刘薇%李冰%谢柏梅
劉楠%劉薇%李冰%謝柏梅
류남%류미%리빙%사백매
轻度认知功能障碍%认知功能评定%脑血管危险因素
輕度認知功能障礙%認知功能評定%腦血管危險因素
경도인지공능장애%인지공능평정%뇌혈관위험인소
Mild cognitive impairment%Mini-mental status estimate%Cerebral vascular%Risk factors
目的：筛查≥50岁门诊头昏、头晕伴记忆力下降中老年人群的的M C I的阳性率并对危险因素进行相关分析。方法对2011-07-2013-07在门诊就诊的以主诉头晕、头昏伴记忆力下降及程度不同的慢性脑供血不足的589例中老年患者。进行面对面调查。调查分为初步筛查、复查诊断两个阶段。初步筛查以简易智能精神状态量（MMSE）、Hachinski缺血评分、焦虑自评量表（SAS）、抑郁自评量表（SDS）、HAMA 及HAMD、临床痴呆评定量表（CDR）评定患者；复查诊断用韦氏成人记忆测验（MQ）。在本项研究中轻度认知功能障碍（MCI）使用Perterson诊断标准并参考国内肖世富对MCI患者的诊断标准，本次研究对象的认知功能评定MMSE24～26分。结果589例患者中，MMSE正常组459例（77.93％），其中MCI 91例，检出率15.45％，男MCI 55例，阳性率9.03％，女36例，阳性率6.12％。不同文化层次MCI的阳性率相比，差异有显著性，随年龄增加而增加，随文化程度的提高而减低；学历、高血压、高血脂、糖尿病与MMSE明显相关。结论在临床工作中，慢性脑供血不足患者和脑血管危险因素是MCI的高危人群。在常规临床诊疗中，增加认知功能量表测试，有助于早期预防和治疗MCI。
目的：篩查≥50歲門診頭昏、頭暈伴記憶力下降中老年人群的的M C I的暘性率併對危險因素進行相關分析。方法對2011-07-2013-07在門診就診的以主訴頭暈、頭昏伴記憶力下降及程度不同的慢性腦供血不足的589例中老年患者。進行麵對麵調查。調查分為初步篩查、複查診斷兩箇階段。初步篩查以簡易智能精神狀態量（MMSE）、Hachinski缺血評分、焦慮自評量錶（SAS）、抑鬱自評量錶（SDS）、HAMA 及HAMD、臨床癡呆評定量錶（CDR）評定患者；複查診斷用韋氏成人記憶測驗（MQ）。在本項研究中輕度認知功能障礙（MCI）使用Perterson診斷標準併參攷國內肖世富對MCI患者的診斷標準，本次研究對象的認知功能評定MMSE24～26分。結果589例患者中，MMSE正常組459例（77.93％），其中MCI 91例，檢齣率15.45％，男MCI 55例，暘性率9.03％，女36例，暘性率6.12％。不同文化層次MCI的暘性率相比，差異有顯著性，隨年齡增加而增加，隨文化程度的提高而減低；學歷、高血壓、高血脂、糖尿病與MMSE明顯相關。結論在臨床工作中，慢性腦供血不足患者和腦血管危險因素是MCI的高危人群。在常規臨床診療中，增加認知功能量錶測試，有助于早期預防和治療MCI。
목적：사사≥50세문진두혼、두훈반기억력하강중노년인군적적M C I적양성솔병대위험인소진행상관분석。방법대2011-07-2013-07재문진취진적이주소두훈、두혼반기억력하강급정도불동적만성뇌공혈불족적589례중노년환자。진행면대면조사。조사분위초보사사、복사진단량개계단。초보사사이간역지능정신상태량（MMSE）、Hachinski결혈평분、초필자평량표（SAS）、억욱자평량표（SDS）、HAMA 급HAMD、림상치태평정량표（CDR）평정환자；복사진단용위씨성인기억측험（MQ）。재본항연구중경도인지공능장애（MCI）사용Perterson진단표준병삼고국내초세부대MCI환자적진단표준，본차연구대상적인지공능평정MMSE24～26분。결과589례환자중，MMSE정상조459례（77.93％），기중MCI 91례，검출솔15.45％，남MCI 55례，양성솔9.03％，녀36례，양성솔6.12％。불동문화층차MCI적양성솔상비，차이유현저성，수년령증가이증가，수문화정도적제고이감저；학력、고혈압、고혈지、당뇨병여MMSE명현상관。결론재림상공작중，만성뇌공혈불족환자화뇌혈관위험인소시MCI적고위인군。재상규림상진료중，증가인지공능량표측시，유조우조기예방화치료MCI。
Objective To evaluate the cognitive function of patients with chronic cerebral circulation insufficiency who were older than 50 years ,and to investigate the significance of adding cognitive function scales in daily clinic service .Methods Patients with chronic cerebral circulation insufficiency were enrolled in the study between July 2011 and July 2013 .The investi-gation included two stages :screening and recheck . The screening stage was completed by mini-mental status estimate (MMSE) ,Hachinski ischemic score ,self-rating anxiety scale ,self-rating depression scale and transcranial Doppler examina-tion .Clinical dementia rating scale ,WMS-RC ,and cranial CT or MRI were performed in the recheck stage .Diagnostic criteria of mild cognitive impairment (MCI) referred to Perterson's diagnosis code and domestic standard .The threshold of MMSE for patients in this study was 24~26 .Results The score of MMSE was normal in 459 of 589 cases (77 .93% ) .MCI patients were 91 cases ;the detection rate was 15 .45% .55 cases of MCI were male and the positive rate was 9 .03% ,36 cases were female and the positive rate was 6 .12% .The detection rate increased with age advancing and decreased with education degree advan-cing .Taking the MMSE score as an independent variable and the age ,sexuality ,educational degree ,cerebrovascular risk fac-tor ,as dependent variable ,linear correlation analysis was accomplished .Significant correlation was found in educational de-gree ,age ,cerebrovascular risk factor (hypertension ,hypertension) and MMSE score .Conclusion In clinical practice ,patients with chronic cerebral circulation insufficiency and cerebrovascular risk factors are high risk group of MCI .Increase the cognitive function scale test is helpful for early prevention and treatment of MCI in clinical routine .
