中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
8期
11-13
,共3页
覃惠洵%刘琳琳%郝洪军%高枫
覃惠洵%劉琳琳%郝洪軍%高楓
담혜순%류림림%학홍군%고풍
寡克隆区带%髓鞘碱性蛋白%髓鞘少突胶质细胞糖蛋白%炎性脱髓鞘%多发性硬化%视神经脊髓炎
寡剋隆區帶%髓鞘堿性蛋白%髓鞘少突膠質細胞糖蛋白%炎性脫髓鞘%多髮性硬化%視神經脊髓炎
과극륭구대%수초감성단백%수초소돌효질세포당단백%염성탈수초%다발성경화%시신경척수염
Oligoclonal bands%Myelin basic protein%Myelin oligodendrocyte glycoprotein%Inflammatory demyelina-tion%M ultiple sclerosis%Neuromyelitis optica
目的：通过观察中枢神经系统炎性脱髓鞘疾病患者寡克隆区带（OCB）、抗髓鞘碱性蛋白（MBP）抗体及抗髓鞘少突胶质细胞糖蛋白（M OG ）抗体的阳性率，为临床诊断提供一定的参考。方法入组91例中枢神经系统炎性脱髓鞘疾病患者为观察组（其中MS 30例，NMO 61例）及50例神经系统非炎性病变患者为对照组。首先分析观察组与对照组间OCB、脑脊液及血清中抗MBP抗体、抗MOG抗体阳性率的差异，再分析观察组中MS亚组及NMO亚组间上述指标阳性率的差异。结果2组比较，OCB、血清抗MBP抗体及血清抗MOG抗体阳性率比较差异有统计学意义（P＜0.05），脑脊液抗MBP抗体及脑脊液抗MOG抗体阳性率比较差异无统计学意义（P＞0.05）。MS亚组与NMO亚组，OCB、血清抗MBP抗体阳性率比较差异有统计学意义（P＜0.05），脑脊液抗MBP抗体、血清抗MOG抗体及脑脊液抗MOG抗体阳性率比较差异无统计学意义（P＞0.05）。结论 OCB阳性对诊断MS具有重要意义。血清抗MBP抗体及抗MOG抗体可为中枢神经系统炎性脱髓鞘疾病的诊断提供重要实验室依据，血清抗MBP抗体在MS与NMO的鉴别诊断中具有一定价值。
目的：通過觀察中樞神經繫統炎性脫髓鞘疾病患者寡剋隆區帶（OCB）、抗髓鞘堿性蛋白（MBP）抗體及抗髓鞘少突膠質細胞糖蛋白（M OG ）抗體的暘性率，為臨床診斷提供一定的參攷。方法入組91例中樞神經繫統炎性脫髓鞘疾病患者為觀察組（其中MS 30例，NMO 61例）及50例神經繫統非炎性病變患者為對照組。首先分析觀察組與對照組間OCB、腦脊液及血清中抗MBP抗體、抗MOG抗體暘性率的差異，再分析觀察組中MS亞組及NMO亞組間上述指標暘性率的差異。結果2組比較，OCB、血清抗MBP抗體及血清抗MOG抗體暘性率比較差異有統計學意義（P＜0.05），腦脊液抗MBP抗體及腦脊液抗MOG抗體暘性率比較差異無統計學意義（P＞0.05）。MS亞組與NMO亞組，OCB、血清抗MBP抗體暘性率比較差異有統計學意義（P＜0.05），腦脊液抗MBP抗體、血清抗MOG抗體及腦脊液抗MOG抗體暘性率比較差異無統計學意義（P＞0.05）。結論 OCB暘性對診斷MS具有重要意義。血清抗MBP抗體及抗MOG抗體可為中樞神經繫統炎性脫髓鞘疾病的診斷提供重要實驗室依據，血清抗MBP抗體在MS與NMO的鑒彆診斷中具有一定價值。
목적：통과관찰중추신경계통염성탈수초질병환자과극륭구대（OCB）、항수초감성단백（MBP）항체급항수초소돌효질세포당단백（M OG ）항체적양성솔，위림상진단제공일정적삼고。방법입조91례중추신경계통염성탈수초질병환자위관찰조（기중MS 30례，NMO 61례）급50례신경계통비염성병변환자위대조조。수선분석관찰조여대조조간OCB、뇌척액급혈청중항MBP항체、항MOG항체양성솔적차이，재분석관찰조중MS아조급NMO아조간상술지표양성솔적차이。결과2조비교，OCB、혈청항MBP항체급혈청항MOG항체양성솔비교차이유통계학의의（P＜0.05），뇌척액항MBP항체급뇌척액항MOG항체양성솔비교차이무통계학의의（P＞0.05）。MS아조여NMO아조，OCB、혈청항MBP항체양성솔비교차이유통계학의의（P＜0.05），뇌척액항MBP항체、혈청항MOG항체급뇌척액항MOG항체양성솔비교차이무통계학의의（P＞0.05）。결론 OCB양성대진단MS구유중요의의。혈청항MBP항체급항MOG항체가위중추신경계통염성탈수초질병적진단제공중요실험실의거，혈청항MBP항체재MS여NMO적감별진단중구유일정개치。
Objective To observe the positive rate of oligoclonal bands (OCB) ,myelin basic protein (MBP) antibody and myelin oligodendrocyte glycoprotein (MOG) antibody in patients of inflammatory central nervous system demyelinating disea-ses ,in order to give help to clinical diagnosis in these kind of diseases.Methods The observation group consisted of 91 cases of inflammatory central nervous system demyelinating diseases (30 cases of MS and 61 cases of NMO) ,and the control group con-sisted of 50 cases of neurological non-inflammatory diseases. The statistical analysis was developed on data of the positive rate of OCB ,MBP and MOG antibody in cerebrospinal fluid and serum between the observation group and control group. The same statistical analysis was also developed between the MS subgroup and NMO subgroup.Results Between the observation group and control group ,the positive rate of OCB ,serum MBP and MOG antibodies were significantly different (P<0.05) ,and the positive rate of cerebrospinal fluid MBP and MOG antibodies were not significantly different (P>0.05). Between the MS sub-group and NMO subgroup ,the positive rate of OCB and serum MBP antibody were significantly different (P<0.05) ,and the positive rate of cerebrospinal fluid MBP antibody ,serum MOG antibody and cerebrospinal fluid MOG antibody were not signifi-cantly different (P>0.05).Conclusion The positive OCB is significant in diagnosis of MS. The serum MBP antibody and ser-um MOG antibody provide an important laboratory basis for the diagnosis of inflammatory central nervous system demyelinating diseases. The serum MBP antibody is probably valuable in differential diagnosis of MS and NMO.
