CAJ | 학술논문

目的：观察安神宁心胶囊对肝郁脾虚、心神失养型失眠症患者睡眠质量的影响。方法将60例失眠症患者随机分为治疗组和对照组，各30例。治疗组给予安神宁心胶囊治疗，每次4丸～6丸，每日3次，温水送服。对照组给予阿普唑仑片口服，每日1次，每次1片，睡前服用。两组均以7 d为1个疗程，连续治疗4个疗程。治疗4周末分别采用匹兹堡睡眠质量指数量表评分法（ PSQ I）和中医临床证候自评量表评分法对睡眠质量、中医临床证候及总体疗效进行评定，同时对两组不良反应发生情况进行统计分析。结果两组治疗后 PSQ I评分在睡眠质量、日间功能障碍、睡眠时间、睡眠效率、睡眠障碍及总分方面差异有统计学意义（ P ＜0．05），在入睡时间、催眠药物方面差异无统计学意义（ P ＞0．05）。治疗组中医临床证候疗效、睡眠质量疗效优于对照组（ P ＜0．05）。治疗组未出现明显不良反应，对照组出现口干、头晕、便秘、唾液增多等不良反应。结论安神宁心胶囊能明显改善肝郁脾虚、心神失养型失眠患者的睡眠质量和临床症状及体征，改善其情志状态和生活质量，安全无副反应，疗效稳定。
목적：관찰안신저심효낭대간욱비허、심신실양형실면증환자수면질량적영향。방법장60례실면증환자수궤분위치료조화대조조，각30례。치료조급여안신저심효낭치료，매차4환～6환，매일3차，온수송복。대조조급여아보서륜편구복，매일1차，매차1편，수전복용。량조균이7 d위1개료정，련속치료4개료정。치료4주말분별채용필자보수면질량지수량표평분법（ PSQ I）화중의림상증후자평량표평분법대수면질량、중의림상증후급총체료효진행평정，동시대량조불량반응발생정황진행통계분석。결과량조치료후 PSQ I평분재수면질량、일간공능장애、수면시간、수면효솔、수면장애급총분방면차이유통계학의의（ P ＜0．05），재입수시간、최면약물방면차이무통계학의의（ P ＞0．05）。치료조중의림상증후료효、수면질량료효우우대조조（ P ＜0．05）。치료조미출현명현불량반응，대조조출현구간、두훈、편비、타액증다등불량반응。결론안신저심효낭능명현개선간욱비허、심신실양형실면환자적수면질량화림상증상급체정，개선기정지상태화생활질량，안전무부반응，료효은정。
Objective To investigate the effect of Anshen N ingxin capsule(ANC) on quality of sleep in insom nia with liver qi stagnation and heart spleen deficiency syndrom e .M ethods S ixty insom nia patients with liver qi stagnation and heart spleen defi-ciency syndrom e were random ly divided into two groups :Contro lgroup(n= 30) treated with alprazo lam tablets and treatm ent group (n = 30) treated with ANC for 4 weeks .P ittsburgh sleep quality index scoring system (PSQ I) and clinical sym ptom s self rating scale scores on sleep quality ,clinical sym ptom s and overal assessm ent of the effectiveness o fChinese m edicine ,and perform ing statistical analysis of adverse reactions were observed.Results There was difference in sleep quality ,and day features ,and sleep tim e ,and sleep efficiency ,and sleep obstacles and the to tal four aspects (P < 0.05) .The curative effects in treatm ent group was significantly higher than tha t in contro l group(P < 0.05) .There was no obvious adverse reaction in treatm ent group.Conclusion ANC could im-prove the quality of sleep in insom nia patients with liver qi stagnation and heart spleen deficiency syndrom e .