CAJ | 학술논문

自噬是广泛存在于真核细胞中的生命现象。已有研究表明，自噬对维持细胞自身的稳定及细胞成分更新保持正常的生理状态起着至关重要的作用。近年来，研究发现自噬与生长发育、肿瘤以及心血管疾病的发生发展密切相关。进一步研究表明，自噬在不同病理环境下既能够促进血管生成，也能够抑制血管的生成。因此，阐释自噬在不同病理环境下调控血管生成的作用机制显得尤为关键。该文对自噬在心血管疾病中的作用尤其是对血管生成的作用研究进展进行综述，着重探讨自噬调控血管生成的作用机制，为后续的科学研究及指导临床提供重要参考。
자서시엄범존재우진핵세포중적생명현상。이유연구표명，자서대유지세포자신적은정급세포성분경신보지정상적생리상태기착지관중요적작용。근년래，연구발현자서여생장발육、종류이급심혈관질병적발생발전밀절상관。진일보연구표명，자서재불동병리배경하기능구촉진혈관생성，야능구억제혈관적생성。인차，천석자서재불동병리배경하조공혈관생성적작용궤제현득우위관건。해문대자서재심혈관질병중적작용우기시대혈관생성적작용연구진전진행종술，착중탐토자서조공혈관생성적작용궤제，위후속적과학연구급지도림상제공중요삼고。
Autophagy is a common phenomenon which widely ex-ists in eukaryotic cells. Researches have shown that autophagy plays a critical role in maintaining cellular hemostasis, cell com-ponents update and keeping a normal physiological state. In re-cent years, the study has found that autophagy is closely related to the growth, the development of cardiovascular diseases and tumors. Further studies show that in different pathological condi-tions, autophagy could both promote angiogenesis and inhibit the formation of blood vessels. Therefore, it is particularly critical to elucidate the mechanisms of autophagy in the regulation of angio-genesis in different pathological conditions. The role of autophagy in cardiovascular diseases especially in the regulation of angio-genesis is discussed in this paper. Besides, the paper also in-cludes the discussion about the mechanisms of autophagy in the regulation angiogenesis, which may provide references for follow-up research and clinical treatment.