CAJ | 학술논문

当今社会生活中酒精滥用现象普遍存在，已成为危害人类健康与公共安全的医学和社会难题。目前研发的多种活性物质能够影响中脑边缘多巴胺神经通路以降低酒精引起的奖赏效应，从而有效改善或治疗酒精依赖综合征。该文综述了近期酒精依赖干预药物的研究进展，旨在为相关机制研究和药物开发提供参考。
당금사회생활중주정람용현상보편존재，이성위위해인류건강여공공안전적의학화사회난제。목전연발적다충활성물질능구영향중뇌변연다파알신경통로이강저주정인기적장상효응，종이유효개선혹치료주정의뢰종합정。해문종술료근기주정의뢰간예약물적연구진전，지재위상관궤제연구화약물개발제공삼고。
Alcohol is widely abused in contemporary social life, which has become a serious medical and social problem because it hurts human health and endangers public safety. Recent re-search has developed several active substances that can effective-ly improve or treat this syndrome via affecting the mesolimbic do-pamine nervous pathway to dampen rewarding effectiveness in-duced by ethanol. This paper reviews the progress in near-term studies of alcoholism-intervening agents, aiming at providing ref-erences for related mechanism exploration and drug development.