CAJ | 학술논문

目的：观察脑梗死大鼠急性期胃黏膜损害性的变化，研究枳实对脑梗死急性期大鼠胃黏膜的保护性作用。方法采用线栓法制备大脑中动脉闭塞局灶性脑缺血大鼠模型，将所有大鼠分为正常对照组、假手术组、脑梗死组、西咪替丁组、枳实组，连续灌胃4 d后处死大鼠，分离胃组织进行电镜观察。结果与正常对照组及假手术组相比，脑梗死大鼠的胃黏膜结构出现明显的组织破坏，枳实组与西咪替丁均能减轻上述组织破坏，且枳实的疗效优于西咪替丁。结论脑梗死急性期胃黏膜出现明显损害，枳实对急性脑梗死导致的胃黏膜损害具有一定的保护性作用。
목적：관찰뇌경사대서급성기위점막손해성적변화，연구지실대뇌경사급성기대서위점막적보호성작용。방법채용선전법제비대뇌중동맥폐새국조성뇌결혈대서모형，장소유대서분위정상대조조、가수술조、뇌경사조、서미체정조、지실조，련속관위4 d후처사대서，분리위조직진행전경관찰。결과여정상대조조급가수술조상비，뇌경사대서적위점막결구출현명현적조직파배，지실조여서미체정균능감경상술조직파배，차지실적료효우우서미체정。결론뇌경사급성기위점막출현명현손해，지실대급성뇌경사도치적위점막손해구유일정적보호성작용。
O bjective To observe the injured biliary changes o f gastric m ucosal lesions in the acute stage of cerebral infarction rats ,and to study the pro tective effect o f C itrus Aurantium on gastric tissue .M ethods The focal cerebral ischem ia rats m odelw ere induced by intralum inalm iddle cerebral artery occlusion.A l rats w ere random ly divided into 5 g roups :Norm al contro l group ,sham operated group cerebral Infarction group ,cim etidine group and C itrus Aurantium group .A l rats w ere kiled after gavage once a day for 4 days .Then the gastric m ucosa o f these anim als w ere exam ined w ith scanning electron m icroscope .Results Com pared w ith no rm al contro lgroup and sham operated g roup ,patho log ical changes in gastric m ucosa w ere found.C itrus Aurantium group and ci-m etidine could am eliorate the gastricm ucosal lesions ,and the curative effects ofC itrus Aurantium w ere m uch better than those of ci-m etidine .Conclusion G astric m ucosa injury appeared after cerebral infarction.C itrus Aurantium has the certain pro tective effect for cerebral infarction.