医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2014年
18期
2390-2392
,共3页
胃黏膜上皮内瘤变%LGIN HGIN%癌变
胃黏膜上皮內瘤變%LGIN HGIN%癌變
위점막상피내류변%LGIN HGIN%암변
Gastric intraepithelial neoplasia%LGIN%HGIN%Canceration
目的：分析胃黏膜上皮内瘤变的临床特征以指导临床。方法：收集自2011年7月-2013年6月我院消化内镜中心所检出的胃黏膜上皮内瘤变患者294例，其中低级别上皮内瘤变（LGIN ）的患者有170例，高级别上皮内瘤变（HGIN）的患者124例，分析它们的临床特征，比较它们在一般情况、病灶形态、HP感染、胃黏膜萎缩、肠化等方面的差异。结果：（1）胃黏膜上皮内瘤变临床常见，老年人多发，以胃窦、胃角常见，同级别上皮内瘤变在性别、年龄、临床症状、病灶形态、HP感染、胃黏膜萎缩肠化等方面无明显差异，P＞0．05。（2）HGIN的发病年龄、HP感染、胃黏膜萎缩肠化率分别为（74．8±13．8）岁、59．7％、46．0％、59．7％，均要明显高于LGIN组[（62．2±14．2）岁、48．2％、34．7％、48．8％]，HGIN癌变率也明显高于LGIN组（49．2％ VS 6．5％），P＜0．05。而两组在性别、临床表现、病变部位及形态上无明显差异。结论：HGIN易癌变，常伴有HP感染、胃黏膜萎缩、肠化，应加强内镜随访。
目的：分析胃黏膜上皮內瘤變的臨床特徵以指導臨床。方法：收集自2011年7月-2013年6月我院消化內鏡中心所檢齣的胃黏膜上皮內瘤變患者294例，其中低級彆上皮內瘤變（LGIN ）的患者有170例，高級彆上皮內瘤變（HGIN）的患者124例，分析它們的臨床特徵，比較它們在一般情況、病竈形態、HP感染、胃黏膜萎縮、腸化等方麵的差異。結果：（1）胃黏膜上皮內瘤變臨床常見，老年人多髮，以胃竇、胃角常見，同級彆上皮內瘤變在性彆、年齡、臨床癥狀、病竈形態、HP感染、胃黏膜萎縮腸化等方麵無明顯差異，P＞0．05。（2）HGIN的髮病年齡、HP感染、胃黏膜萎縮腸化率分彆為（74．8±13．8）歲、59．7％、46．0％、59．7％，均要明顯高于LGIN組[（62．2±14．2）歲、48．2％、34．7％、48．8％]，HGIN癌變率也明顯高于LGIN組（49．2％ VS 6．5％），P＜0．05。而兩組在性彆、臨床錶現、病變部位及形態上無明顯差異。結論：HGIN易癌變，常伴有HP感染、胃黏膜萎縮、腸化，應加彊內鏡隨訪。
목적：분석위점막상피내류변적림상특정이지도림상。방법：수집자2011년7월-2013년6월아원소화내경중심소검출적위점막상피내류변환자294례，기중저급별상피내류변（LGIN ）적환자유170례，고급별상피내류변（HGIN）적환자124례，분석타문적림상특정，비교타문재일반정황、병조형태、HP감염、위점막위축、장화등방면적차이。결과：（1）위점막상피내류변림상상견，노년인다발，이위두、위각상견，동급별상피내류변재성별、년령、림상증상、병조형태、HP감염、위점막위축장화등방면무명현차이，P＞0．05。（2）HGIN적발병년령、HP감염、위점막위축장화솔분별위（74．8±13．8）세、59．7％、46．0％、59．7％，균요명현고우LGIN조[（62．2±14．2）세、48．2％、34．7％、48．8％]，HGIN암변솔야명현고우LGIN조（49．2％ VS 6．5％），P＜0．05。이량조재성별、림상표현、병변부위급형태상무명현차이。결론：HGIN역암변，상반유HP감염、위점막위축、장화，응가강내경수방。
Objective :This study was designed to analysis the clinical features of gastric mucosa intraepithelial neopla-sia .To guide clinical treatment .Methods :Collected 294 patients with gastric IN which confirmed by biopsy in our diges-tive endoscopy center since July 2011 to June 2013 ,the 170 cases were low-grade intraepithelial neoplasia (LGIN) and 124 cases were high-grade intraepithelial neoplasia (HGIN ) .Analyzed their clinical features ,compared their differ-ences in the general case ,the lesion morphology ,HP infection ,intestinal mucosal atrophy and other aspects .Results:(1) In clinical gastric mucosa intraepithelial neoplasia is very commom ,especially in the elderly ,mainly occurred in gastric antrum and angle of stomach .There are no significant differences in gender ,age ,clinical symptoms ,lesion morphology ,HP infection ,intestinal mucosal atrophy and so among the same level intraepithelial neoplasia cases .(2) The onset age ,HP infection rate ,intestinal mucosal atrophy rate of HGIN group respectively are (74.8 ± 13 .8)years old ,59 .7% ,46 .0% and 59 .7% ,are significantly higher than those of LGIN group[(62 .2 ± 14 .2) years old ,48 .2% , 34 .7% ,48 .8% ] .The canceration rate of HGIN group is also significantly higher than LGIN group (49 .2% VS 6.5% ) . The two groups have no significant differences in gender ,clinical manifestations ,and morphology of the lesion .Conclu-sion:HGIN is prone to turning cancerous ,often accompanied by HP infection ,gastric intestinal metaplasia atrophy ,en-doscopic follow-up should be strengthened .
