CAJ | 학술논문

目的：研究帕洛诺司琼预防腹腔镜胆囊切除术后恶心呕吐的有效性和安全性。方法：选择在全身麻醉下行腹腔镜胆囊切除术的患者60例，ASAⅠ～Ⅱ级，随机分成2组：帕洛诺司琼组（P组）和昂丹司琼组（O组），每组30例。于麻醉诱导前，P组给予帕洛诺司琼0．25mg静脉注射，O组给予昂丹司琼4．0mg静脉注射。观察并记录患者术后0～3h、3～24h、24～48h三个时间段内恶心呕吐的情况及完全缓解率（Complete Response Rate ，CRR）。结果：两组术后0～3h、3～24h、24～48h的CRR比较（P组 VS O 组）：93．3％ VS 83．3％（P＞0．05），90.0％ VS 80.0％（P＞0.05），90.0％ VS 60.0％（P＜0．05）。结论：与昂丹司琼比较，帕洛诺司琼可更显著地降低腹腔镜胆囊切除术后48h内恶心呕吐的发生率，在临床应用中是有效和安全的。
목적：연구파락낙사경예방복강경담낭절제술후악심구토적유효성화안전성。방법：선택재전신마취하행복강경담낭절제술적환자60례，ASAⅠ～Ⅱ급，수궤분성2조：파락낙사경조（P조）화앙단사경조（O조），매조30례。우마취유도전，P조급여파락낙사경0．25mg정맥주사，O조급여앙단사경4．0mg정맥주사。관찰병기록환자술후0～3h、3～24h、24～48h삼개시간단내악심구토적정황급완전완해솔（Complete Response Rate ，CRR）。결과：량조술후0～3h、3～24h、24～48h적CRR비교（P조 VS O 조）：93．3％ VS 83．3％（P＞0．05），90.0％ VS 80.0％（P＞0.05），90.0％ VS 60.0％（P＜0．05）。결론：여앙단사경비교，파락낙사경가경현저지강저복강경담낭절제술후48h내악심구토적발생솔，재림상응용중시유효화안전적。
Objective :To observe the clinical safety and effect of palonosetron for preventing postoperative nausea and vomiting after laparoscopic cholecystectomy .Methods:60 patients undergoing general anesthesia for laparoscopic chole-cystectomy ,ASA Ⅰ ~ Ⅱ ,were randomly divided into two groups :the palonosetron group(Group P) ,Ondansetron group(Group O) ,n=30 each .The patients of group P were given palonosetron 0 .25mg and group O were given ondan-setron 4 .0mg i .v injection before anesthesia induction .The incidence of nausea ,vomiting and complete response rate during 0~3 hours ,3~24 hours ,24~48 hours in the postoperative period was observed and recorded .Results:The inci-dence of complete response rate between group P and group O (gourp P VS group O)was 93 .3% VS 83 .3% (P>0.05)(0~3 hours postoperative) ,90 .0% VS 80 .0% (P>0.05)(3~24 hours postoperative) ,90 .0% VS 60 .0% (P<0.05)(24~48 hours postoperative) .Conclusion:Prophylactic therapy with palonosetron is more effective than ondanse-tron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy in 48 hours ,which provide a safe and effective compatibility program in clinical .