CAJ | 학술논문

目的：探讨非痴呆型血管性认知功能障碍(VCIND)与血清胱抑素C(Cys-C)水平的关系。方法64例非痴呆型血管性认知功能障碍患者设为VCIND组,45例具有脑血管病危险因素无认知功能障碍患者设为对照组,对患者的Cys-C水平进行测定,并同时进行Hachinski缺血指数量表(HIS)、临床痴呆量表(CDR)评分。结果 VCIND组的Cys-C水平高于对照组且差异具有统计学意义(P<0.05)；VCIND组Cys-C 水平与HIS评分(r=-0.514)、CDR评分(r=-0.596)均存在负相关(r<0,P<0.001)。结论 VCIND组的Cys-C水平高于对照组, Cys-C水平升高可能是非痴呆型血管性认知功能障碍的危险因素。
목적：탐토비치태형혈관성인지공능장애(VCIND)여혈청광억소C(Cys-C)수평적관계。방법64례비치태형혈관성인지공능장애환자설위VCIND조,45례구유뇌혈관병위험인소무인지공능장애환자설위대조조,대환자적Cys-C수평진행측정,병동시진행Hachinski결혈지수량표(HIS)、림상치태량표(CDR)평분。결과 VCIND조적Cys-C수평고우대조조차차이구유통계학의의(P<0.05)；VCIND조Cys-C 수평여HIS평분(r=-0.514)、CDR평분(r=-0.596)균존재부상관(r<0,P<0.001)。결론 VCIND조적Cys-C수평고우대조조, Cys-C수평승고가능시비치태형혈관성인지공능장애적위험인소。
Objective To investigate the relationship between vascular cognitive impairment no dementia (VCIND) and cystatin C (Cys-C).Methods A total of 64 cases of VCIND were selected as the VCIND group, and 45 cases with risk factors of cerebrovascular disease and no cognitive disorder were treated as the control group. The Cys-C level was detected, and the Haehimki ischemia index scale (HIS) and the clinical dementia rating scale (CDR) were scored.Results The level of Cys-C in VCIND group was higher than that of the control group, and the difference was statistically significant (P<0.05). In the VCIND group, level of Cys-C had negative correlation with HIS score (r=-0.514) and CDR score (r=-0.596) (r<0,P<0.001).Conclusion Cys-C level in the VCIND group is higher than that in the control group, and increased Cys-C level probably is the risk factors of VCIND.