中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
12期
44-45,46
,共3页
胆碱酯酶%小儿危重病例评分%多系统器官功能衰竭
膽堿酯酶%小兒危重病例評分%多繫統器官功能衰竭
담감지매%소인위중병례평분%다계통기관공능쇠갈
Cholinesterase%Pediatric critical illness scoring%Multiple system organ failure
目的：探讨血清胆碱酯酶对危重儿病危程度及预后的判断价值。方法：按小儿危重病例评分法（PCIS）进行评分，选取2011年3月-2013年11月收入本院儿科病房的225例患儿，将其分为非危重组（评分>81分）80例、危重组（评分71~81分）80例、极危重组（评分<71分）65例，分别于入院后24 h内检测血清胆碱酯酶活性，并用多系统器官功能衰竭（MSOF）诊断标准评价系统器官功能，分析血清胆碱酯酶、PCIS评分、MSOF之间的相关性。结果：极危重组血清胆碱酯酶活性明显低于危重组，危重组明显低于非危重组，不同PCIS评分组间的血清胆碱酯酶、MSOF发生率与死亡率比较，PCIS评分越低，血清胆碱酯酶活性越低，多器官功能衰竭发生率越高，死亡率越高，差异均有统计学意义（P<0.01）。结论：危重病例评分越低者，血清胆碱酯酶活性下降越明显，多器官功能衰竭发生率越高及病死率越高，故血清胆碱酯酶活性测定可作为评判危重儿病危程度及预后的一项指标。
目的：探討血清膽堿酯酶對危重兒病危程度及預後的判斷價值。方法：按小兒危重病例評分法（PCIS）進行評分，選取2011年3月-2013年11月收入本院兒科病房的225例患兒，將其分為非危重組（評分>81分）80例、危重組（評分71~81分）80例、極危重組（評分<71分）65例，分彆于入院後24 h內檢測血清膽堿酯酶活性，併用多繫統器官功能衰竭（MSOF）診斷標準評價繫統器官功能，分析血清膽堿酯酶、PCIS評分、MSOF之間的相關性。結果：極危重組血清膽堿酯酶活性明顯低于危重組，危重組明顯低于非危重組，不同PCIS評分組間的血清膽堿酯酶、MSOF髮生率與死亡率比較，PCIS評分越低，血清膽堿酯酶活性越低，多器官功能衰竭髮生率越高，死亡率越高，差異均有統計學意義（P<0.01）。結論：危重病例評分越低者，血清膽堿酯酶活性下降越明顯，多器官功能衰竭髮生率越高及病死率越高，故血清膽堿酯酶活性測定可作為評判危重兒病危程度及預後的一項指標。
목적：탐토혈청담감지매대위중인병위정도급예후적판단개치。방법：안소인위중병례평분법（PCIS）진행평분，선취2011년3월-2013년11월수입본원인과병방적225례환인，장기분위비위중조（평분>81분）80례、위중조（평분71~81분）80례、겁위중조（평분<71분）65례，분별우입원후24 h내검측혈청담감지매활성，병용다계통기관공능쇠갈（MSOF）진단표준평개계통기관공능，분석혈청담감지매、PCIS평분、MSOF지간적상관성。결과：겁위중조혈청담감지매활성명현저우위중조，위중조명현저우비위중조，불동PCIS평분조간적혈청담감지매、MSOF발생솔여사망솔비교，PCIS평분월저，혈청담감지매활성월저，다기관공능쇠갈발생솔월고，사망솔월고，차이균유통계학의의（P<0.01）。결론：위중병례평분월저자，혈청담감지매활성하강월명현，다기관공능쇠갈발생솔월고급병사솔월고，고혈청담감지매활성측정가작위평판위중인병위정도급예후적일항지표。
Objective:To explore the value of serum cholinesterase in determining the disease severity and prognosis in critical ill children.Method:225 pediatric patients were admitted in our pediatric wards from March 2011 to November 2013.According to Pediatric Critical Illness Score(PCIS),they were divided into the non-critical ill group for 80 cases(>81 points),the critical ill group for 80 cases(71-81 points)and the extremely critical ill group for 65 cases(<71 points).The serum cholinesterase activity was detected within 24 hours after admission.The system and organs functions were evaluated according to the diagnostic criteria of Multi-Organ System Failure(MSOF).The correlation of serum cholinesterase and PCIS score and MSOF was analyzed.Result:Serum cholinesterase activity in the extremely critical ill group was significantly lower than the critical ill group,and that in the critical ill group was significantly lower than the non-critical ill group.The serum cholinesterase,MSOF incidence and mortality were compared among different groups with different PCIS scores.It was found that the lower the PCIS score,the lower the serum cholinesterase activity,the higher the MSOF incidence,the higher the mortality,the differences were statistically significant(P<0.01).Conclusion:According to our results,the lower the PCIS score,the lower the serum cholinesterase activity,the higher the MSOF incidence and the mortality.Therefore,determining serum cholinesterase activity may be an indicator of determining the disease severity and prognosis in critical ill children.
