中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
12期
37-38
,共2页
涎腺腺样囊性癌%血管内皮生长因子%RNA干扰%侵袭
涎腺腺樣囊性癌%血管內皮生長因子%RNA榦擾%侵襲
연선선양낭성암%혈관내피생장인자%RNA간우%침습
Salivary adenoid cystic carcinoma%Vasculare endothelial growth factor%RNA interference%Invasiveness
目的：利用RNAi技术沉默腺样囊性癌细胞株ACC-2中VEGF的表达，探讨其对肿瘤细胞侵袭能力的影响。方法：利用RNAi技术沉默VEGF表达，用Transwell侵袭实验检测细胞体外侵袭能力的变化。结果：与对照组比较，VEGF的siRNA能有效地抑制实验组ACC-2细胞的侵袭能力。结论：沉默VEGF减弱腺样囊性癌的侵袭能力。
目的：利用RNAi技術沉默腺樣囊性癌細胞株ACC-2中VEGF的錶達，探討其對腫瘤細胞侵襲能力的影響。方法：利用RNAi技術沉默VEGF錶達，用Transwell侵襲實驗檢測細胞體外侵襲能力的變化。結果：與對照組比較，VEGF的siRNA能有效地抑製實驗組ACC-2細胞的侵襲能力。結論：沉默VEGF減弱腺樣囊性癌的侵襲能力。
목적：이용RNAi기술침묵선양낭성암세포주ACC-2중VEGF적표체，탐토기대종류세포침습능력적영향。방법：이용RNAi기술침묵VEGF표체，용Transwell침습실험검측세포체외침습능력적변화。결과：여대조조비교，VEGF적siRNA능유효지억제실험조ACC-2세포적침습능력。결론：침묵VEGF감약선양낭성암적침습능력。
Objective:To investigate the inhibitory effects of VEGF targeted small interference RNA(siRNA)on invasiveness of salivary adenoid cystic carcinoma(SACC)cell line ACC-2. Method:VEGFsiRNA was transfect into SACC cell line ACC-2 and then examine the changes of invasive ability of ACC-M. Result:The invasive and proliferative abilities of ACC-2 decreased,and the difference between the two groups were statistically significant(P<0.05). Conclusion:Si-VEGF can effectively decrease invasiveness of SACC cells.
