肿瘤影像学
腫瘤影像學
종류영상학
Oncoradiology
2014年
1期
58-60
,共3页
2型糖尿病%颈动脉内-中膜厚度%血流最大剪切率%回声跟踪技术
2型糖尿病%頸動脈內-中膜厚度%血流最大剪切率%迴聲跟蹤技術
2형당뇨병%경동맥내-중막후도%혈류최대전절솔%회성근종기술
Type 2 diabetes%Carotid artery intima-media thickness%Maximal shear rate%Echo-tracking technique
目的:探讨2型糖尿病患者颈动脉弹性功能、血流最大剪切率(SR)及内-中膜厚度(IMT)的相关性。方法40例健康人作为正常对照,65例2型糖尿患者分为病程≤5年组(A组)和病程>5年组(B组)。利用高频超声对所有观察对象的颈动脉进行测量,包括颈动脉IMT、收缩期峰值流速(PSV)。利用血管回声跟踪(ET)技术测量相关参数,包括血管舒张期内径(Dd)、压力应变弹性系数(Ep),硬度指数(β)、顺应性(AC)。结果与对照组比较,糖尿病A组Ep、β增高(P<0.01),AC降低(P<0.05),IMT、PSV、Dd、SR差异无统计学意义;与糖尿病A组和对照组比较,糖尿病B组颈动脉IMT增厚(P<0.01),Dd增宽(P<0.01),PSV、SR降低(P<0.01),Ep、β增高(P<0.01),AC降低(P<0.05)。Ep、β与IMT呈正相关(r=0.527、0.556,P<0.01),与SR呈负相关(r =-0.513、-0.537, P<0.01),AC与IMT呈负相关(r=-0.477,P<0.01),与SR呈正相关(r=4.58,P<0.01),IMT与SR呈负相关(r=-0.537,P<0.01)。结论2型糖尿病患者颈动脉弹性变化要早于IMT、SR改变,而低SR加速了血管内皮功能的损伤及动脉硬化的发展。
目的:探討2型糖尿病患者頸動脈彈性功能、血流最大剪切率(SR)及內-中膜厚度(IMT)的相關性。方法40例健康人作為正常對照,65例2型糖尿患者分為病程≤5年組(A組)和病程>5年組(B組)。利用高頻超聲對所有觀察對象的頸動脈進行測量,包括頸動脈IMT、收縮期峰值流速(PSV)。利用血管迴聲跟蹤(ET)技術測量相關參數,包括血管舒張期內徑(Dd)、壓力應變彈性繫數(Ep),硬度指數(β)、順應性(AC)。結果與對照組比較,糖尿病A組Ep、β增高(P<0.01),AC降低(P<0.05),IMT、PSV、Dd、SR差異無統計學意義;與糖尿病A組和對照組比較,糖尿病B組頸動脈IMT增厚(P<0.01),Dd增寬(P<0.01),PSV、SR降低(P<0.01),Ep、β增高(P<0.01),AC降低(P<0.05)。Ep、β與IMT呈正相關(r=0.527、0.556,P<0.01),與SR呈負相關(r =-0.513、-0.537, P<0.01),AC與IMT呈負相關(r=-0.477,P<0.01),與SR呈正相關(r=4.58,P<0.01),IMT與SR呈負相關(r=-0.537,P<0.01)。結論2型糖尿病患者頸動脈彈性變化要早于IMT、SR改變,而低SR加速瞭血管內皮功能的損傷及動脈硬化的髮展。
목적:탐토2형당뇨병환자경동맥탄성공능、혈류최대전절솔(SR)급내-중막후도(IMT)적상관성。방법40례건강인작위정상대조,65례2형당뇨환자분위병정≤5년조(A조)화병정>5년조(B조)。이용고빈초성대소유관찰대상적경동맥진행측량,포괄경동맥IMT、수축기봉치류속(PSV)。이용혈관회성근종(ET)기술측량상관삼수,포괄혈관서장기내경(Dd)、압력응변탄성계수(Ep),경도지수(β)、순응성(AC)。결과여대조조비교,당뇨병A조Ep、β증고(P<0.01),AC강저(P<0.05),IMT、PSV、Dd、SR차이무통계학의의;여당뇨병A조화대조조비교,당뇨병B조경동맥IMT증후(P<0.01),Dd증관(P<0.01),PSV、SR강저(P<0.01),Ep、β증고(P<0.01),AC강저(P<0.05)。Ep、β여IMT정정상관(r=0.527、0.556,P<0.01),여SR정부상관(r =-0.513、-0.537, P<0.01),AC여IMT정부상관(r=-0.477,P<0.01),여SR정정상관(r=4.58,P<0.01),IMT여SR정부상관(r=-0.537,P<0.01)。결론2형당뇨병환자경동맥탄성변화요조우IMT、SR개변,이저SR가속료혈관내피공능적손상급동맥경화적발전。
Objective To probe the relationship among artery elasticity, maximal shear rate (SR) and intima-media thickness (IMT) of the carotid arteries in the patients with type 2 diabetes. Methods 40 healthy volunteers were set as controls. 65 cases with type 2 diabetes were divided into two groups according to diabetes course: ≤5 years as group A and>5 years as group B. In all subjects, the IMT, peak systolic velocity (PSV) of carotid arteries were measured with high resolution ultrasound. The diastolic diameter (Dd), pressure-strain elastic modulus (Ep), stiffness parameter(β) and arterial compliance (AC) were detected by echo-tracking (ET) technique. Results Compared with the control group, the Ep and β in group A were significantly higher (P<0.01), and AC was lower (P<0.05), while IMT, PSV, Dd, SR were not significantly different between the two groups. Compared with group B, the Ep, β, IMT and Dd were increased (P<0.01), PSV and SR were decreased (P<0.01), and AC was increased (P<0.05). Ep andβshowed a significant positive correlation with IMT (r=0.527 and 0.556,P<0.01) and a significant negative correlation with SR (r=-0.513 and -0.537,P<0.01). AC showed a negative correlation with IMT(r=-0.477,P<0.01) and a positive correlation with SR (r=4.58,P<0.01). SR showed a negative correlation with IMT (r=-0.537,P<0.01). Conclusion The change in arterial elasticity in the patients with type 2 diabetes appears earlier than IMT and SR. Lower SR could accelerate the injury of vascular endothelial function and the progress of arteriosclerosis.