CAJ | 학술논문

目的：探讨99mTc-HYNIC-TOC显像探测神经内分泌肿瘤肝（NET）转移灶的价值。方法对17例行99mTc-HYNIC-TOC检查的NET肝转移患者进行回顾性分析，其原发灶为直肠NET者13例、胰腺NET者3例、腹腔来源NET者1例。静脉注射10~15 mCi 99mTc-HYNIC-TOC后2 h行全身和腹部SPECT/CT断层显像，对各肝脏转移灶进行图像分析，测量靶/非靶放射性计数比值（T/NT）。结果99mTc-HYNIC-TOC对NET患者肝转移的诊断阳性率为76.5%（13/17），阳性病灶T/NT比值平均为3.73±2.57（1.50~13.03，n=46），病灶检出率为92.0%（46/50），同机低剂量CT和同期增强诊断CT病灶检出率分别为40.0%（20/50）和64.7%（11/17）。99mTc-HYNIC-TOC SPECT/CT检出最小病灶最大径仅7 mm，T/NT值达2.68。此外，全身平面显像配合SPECT/CT断层显像可更准确发现更多肝内转移灶，对肝转移灶疗效评价也有较好的应用价值。结论99mTc-HYNIC-TOC SPECT/CT显像可准确、灵敏地探测肝转移灶。
목적：탐토99mTc-HYNIC-TOC현상탐측신경내분비종류간（NET）전이조적개치。방법대17례행99mTc-HYNIC-TOC검사적NET간전이환자진행회고성분석，기원발조위직장NET자13례、이선NET자3례、복강래원NET자1례。정맥주사10~15 mCi 99mTc-HYNIC-TOC후2 h행전신화복부SPECT/CT단층현상，대각간장전이조진행도상분석，측량파/비파방사성계수비치（T/NT）。결과99mTc-HYNIC-TOC대NET환자간전이적진단양성솔위76.5%（13/17），양성병조T/NT비치평균위3.73±2.57（1.50~13.03，n=46），병조검출솔위92.0%（46/50），동궤저제량CT화동기증강진단CT병조검출솔분별위40.0%（20/50）화64.7%（11/17）。99mTc-HYNIC-TOC SPECT/CT검출최소병조최대경부7 mm，T/NT치체2.68。차외，전신평면현상배합SPECT/CT단층현상가경준학발현경다간내전이조，대간전이조료효평개야유교호적응용개치。결론99mTc-HYNIC-TOC SPECT/CT현상가준학、령민지탐측간전이조。
Objective To evaluate the value of 99mTc-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) in detection of liver metastases in patients with neuroendocrine tumors. Methods 99mTc-HYNIC-TOC imaging data of 17 neuroendocrine tumor patients with liver metastases were analyzed retrospectively, including 13 rectal, 3 pancreatic and 1 abdominal neuroendocrine tumors. Total body imaging and SPECT/CT imaging were obtained 2 h after intravenous injection of 10-15 mCi 99mTc-HYNIC-TOC. Results 76.5% (13/17) of neuroendocrine tumor patients with liver metastases were positive on 99mTc-HYNIC-TOC imaging. The average target/non-target (T/NT) value of positive lesions was 3.73±2.57 (1.50~13.03, n=46). The detection rate for all the lesions was 92.0% (46/50). The detection rates of TOC imaging with low-dose CT and normal-dose CT were 40.0%(20/50) and 64.7%(11/17) respectively. The size of the smallest lesion detected was only 7 mm, with T/NT value of 2.68. Besides, SPECT/CT scan could provide more correct information than planar imaging. Conclusion 99mTc-HYNIC-TOC SPECT/CT is an excellent method for detection of liver metastases in the patients with neuroendocrine tumors.