CAJ | 학술논문

目的：探讨鼻咽癌患者治疗期间血红蛋白浓度的变化对局部控制的影响。方法将443例鼻咽癌患者治疗期间血红蛋白浓度的变化分为血红蛋白上升组141例和血红蛋白下降组302例。前组行单纯放疗51例，放疗+化疗90例；后组予单纯放疗110例，放疗+化疗192例。放疗为常规放疗，化疗为诱导化疗和同步放化疗。分析患者血红蛋白浓度的变化与预后的关系。结果鼻咽癌治疗期间血红蛋白上升组患者和血红蛋白下降组患者的5年无局部复发生存率分别为53.5%和37.5%（P=0.013），5年无远处转移生存率分别为58.5%和37.4%（P=0.009），5年总生存率分别为43.3%和27.7%（P=0.003）。多因素分析显示患者年龄跃60岁、治疗前和治疗期贫血、T分期及治疗期血红蛋白上升是影响鼻咽癌患者局部控制的独立预后因素。结论鼻咽癌患者治疗期间血红蛋白浓度上升是影响局部控制的预后因素之一。
목적：탐토비인암환자치료기간혈홍단백농도적변화대국부공제적영향。방법장443례비인암환자치료기간혈홍단백농도적변화분위혈홍단백상승조141례화혈홍단백하강조302례。전조행단순방료51례，방료+화료90례；후조여단순방료110례，방료+화료192례。방료위상규방료，화료위유도화료화동보방화료。분석환자혈홍단백농도적변화여예후적관계。결과비인암치료기간혈홍단백상승조환자화혈홍단백하강조환자적5년무국부복발생존솔분별위53.5%화37.5%（P=0.013），5년무원처전이생존솔분별위58.5%화37.4%（P=0.009），5년총생존솔분별위43.3%화27.7%（P=0.003）。다인소분석현시환자년령약60세、치료전화치료기빈혈、T분기급치료기혈홍단백상승시영향비인암환자국부공제적독립예후인소。결론비인암환자치료기간혈홍단백농도상승시영향국부공제적예후인소지일。
Objective To examine whether changes in hemoglobin concentration during treatment local control therapy of nasopha-ryngeal carcinoma (NPC)can predict outcomes. Methods A total of 443 patients with NPC were classified into two groups:one group experienced an increase in hemoglobin concentration during radiotherapy (n=51)or a combination of radiotherapy and chemotherapy (n=90);the other group experienced a decrease in hemoglobin after radiotherapy (n=110)or a combination of radiotherapy and chemotherapy(n=192).Relationships between hemoglobin concentration changes and survival outcomes were analyzed. Results The group experiencing an increase in hemoglobin presented significantly greater rates of 5-year local relapse-free survival (53.5% vs 37.5%, P=0.013),5-year distant metastasis-free survival(58.5%vs 37.4%,P=0.009)and 5-year overall survival(43.3%vs 27.7%,P=0.003). Multivariate analysis identified age>60 years,patients with Anemia before and during treatmen,T staging and changes in hemoglobin concentration during treatment as independent prognostic factors for failure of local control therapy. Conclusion An increase in hemoglobin concentration during treatment is a prognostic factor for local control of NPC.