CAJ | 학술논문

目的：检测去唾液酸糖蛋白受体2（asialoglycoprotein receptor 2，ASGR2）基因在肝细胞性肝癌（hepatocellular carcinoma，HCC）中的表达水平，探讨ASGR2在HCC发生、发展中的作用和意义。方法以RT-PCR法检测55例HCC患者、55例非肝癌的其他肿瘤患者和33例非肿瘤的其他疾病对照患者外周血液中ASGR2基因的表达水平，并分析其意义。结果肝癌组和非肝癌的其他肿瘤组患者血液中ASGR2基因阳性表达率分别为85.5豫、65.5%，两组差异有统计学意义（P<0.05），肝癌组和非肿瘤的其他疾病对照组ASGR2基因阳性表达率分别为85.5%、78.8%，两组差异无统计学意义（P>0.05），ASGR2基因在3组患者外周血液中的表达水平有明显差异（P<0.05）。ASGR2基因的表达与HCC患者的性别、年龄、AFP、肝硬化、肿瘤家族史等临床病理特征均无统计学意义（P>0.05）。结论 ASGR2基因的表达水平可能与HCC发生、发展有关，检测ASGR2的水平有望作为HCC早期发病的预测指标。
목적：검측거타액산당단백수체2（asialoglycoprotein receptor 2，ASGR2）기인재간세포성간암（hepatocellular carcinoma，HCC）중적표체수평，탐토ASGR2재HCC발생、발전중적작용화의의。방법이RT-PCR법검측55례HCC환자、55례비간암적기타종류환자화33례비종류적기타질병대조환자외주혈액중ASGR2기인적표체수평，병분석기의의。결과간암조화비간암적기타종류조환자혈액중ASGR2기인양성표체솔분별위85.5예、65.5%，량조차이유통계학의의（P<0.05），간암조화비종류적기타질병대조조ASGR2기인양성표체솔분별위85.5%、78.8%，량조차이무통계학의의（P>0.05），ASGR2기인재3조환자외주혈액중적표체수평유명현차이（P<0.05）。ASGR2기인적표체여HCC환자적성별、년령、AFP、간경화、종류가족사등림상병리특정균무통계학의의（P>0.05）。결론 ASGR2기인적표체수평가능여HCC발생、발전유관，검측ASGR2적수평유망작위HCC조기발병적예측지표。
Objective To explore the expression and possible significance of asialoglycoprotein receptor 2 (ASGR2)gene in hepato-cellular carcinoma(HCC). Methods Expression of the ASGR2 gene in peripheral blood was detected by RT-PCR in 55 patients with hepatocellular carcinoma,55 patients with non-HCC tumors,and 33 non-tumor control patients. Results Expression of the ASGR2 gene was detected in significantly more HCC patients(85.5%)than in non-HCC patients(65.5%,P<0.05);in fact,the rate of positive expression was similar among HCC patients as in non-cancer controls(78.8%,P>0.05).Gene expression differed significantly across all three patient groups(P<0.05).ASGR2 gene expression was not significantly associated with clinicopathological features of HCC,age, AFP,cirrhosis,or cancer family history(P>0.05). Conclusion ASGR2 gene expression may be associated with HCC development, and detecting expression may serve as an early predictor of pathogenesis.