CAJ | 학술논문

目的：探讨TP方案诱导化疗联合放疗治疗晚期鼻咽癌的疗效。方法以应用TP方案诱导化疗联合放疗治疗晚期鼻咽癌疼痛的55例患者作为联合组，以单纯应用放疗的53例晚期鼻咽癌疼痛患者作为对照组，观察两组患者鼻咽部病灶、颈部淋巴结转移及疼痛缓解情况。结果联合组患者鼻咽部病灶、颈部淋巴结转移改善情况及疼痛缓解效果均显著优于对照组，差异有统计学意义（P<0.05）。结论 TP方案诱导化疗联合放疗对局部晚期鼻咽癌患者的近期疗效明显优于单纯放疗，可于临床进一步应用。
목적：탐토TP방안유도화료연합방료치료만기비인암적료효。방법이응용TP방안유도화료연합방료치료만기비인암동통적55례환자작위연합조，이단순응용방료적53례만기비인암동통환자작위대조조，관찰량조환자비인부병조、경부림파결전이급동통완해정황。결과연합조환자비인부병조、경부림파결전이개선정황급동통완해효과균현저우우대조조，차이유통계학의의（P<0.05）。결론 TP방안유도화료연합방료대국부만기비인암환자적근기료효명현우우단순방료，가우림상진일보응용。
Objective To explore the effectiveness of TP induction chemotherapy followed by radiotherapy for patients of local advanced nasopharyngeal carcinoma. Methods A total of 108 cases of local advanced nasopharyngeal carcinoma were in-cluded in this study. Fifty-five cases were treated with TP induction chemotherapy followed by radiotherapy as the union group, whereas other fifty-three cases were treated merely with radiotherapy as control group. Nasopharyngeal lesions, neck lymph node metastasis and pain relief were observed and compared between two groups. Results The nasopharyngeal lesions, metas-tasizing neck lymph nodes and cancer pain were all relieved in different degrees in the union group and the effectiveness were superior to that of control group. Differences had statistical significance between two groups (P<0.05). Conclusion TP induction chemotherapy followed by radiotherapy has better short-term effectiveness than simple radiotherapy. It can effectively relieve pain of patients and could be further applied in clinic.