CAJ | 학술논문

目的：探讨大黄素对肝纤维化大鼠肝脏氧化应激的影响。方法：采用复合致病因素法建立肝纤维化大鼠模型并以大黄素(40 mg/kg,每日灌胃)进行干预。4周末取材,行血浆肝功能及肝纤维化4项指标检测；观察肝组织病理学变化、检测肝组织匀浆中肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、一氧化氮(NO)、过氧亚硝基阴离子(ONOO-)含量。结果：大鼠肝纤维化模型复制成功,模型组大鼠肝组织匀浆TNF-α、MDA、NO、ONOO-含量明显增加；大黄素干预组肝脏病理性损伤较模型组明显减轻,肝组织TNF-α、MDA、NO、ONOO-含量明显降低。结论：该种剂量大黄素可以通过降低肝脏的氧化应激水平,对肝脏纤维化的形成发挥一定的保护作用。
목적：탐토대황소대간섬유화대서간장양화응격적영향。방법：채용복합치병인소법건립간섬유화대서모형병이대황소(40 mg/kg,매일관위)진행간예。4주말취재,행혈장간공능급간섬유화4항지표검측；관찰간조직병이학변화、검측간조직균장중종류배사인자-α(TNF-α)、병이철(MDA)、일양화담(NO)、과양아초기음리자(ONOO-)함량。결과：대서간섬유화모형복제성공,모형조대서간조직균장TNF-α、MDA、NO、ONOO-함량명현증가；대황소간예조간장병이성손상교모형조명현감경,간조직TNF-α、MDA、NO、ONOO-함량명현강저。결론：해충제량대황소가이통과강저간장적양화응격수평,대간장섬유화적형성발휘일정적보호작용。
Objective:To explore the protective effect of emodin on oxidative stress in liver of hepatic fibrosis rats.Methods:The hepatic fibrosis rat model was established with multiple pathogenic factors and treated with emodin (40 mg/kg)for 4 weeks.The biochemistry indexes of ET,AST,ALT,TB,TC,TG and hepatic fibrosis indexes HA,LN,Ⅳ-C,PCⅢ were detected;The histopathological changes of hepatic tissues were observed and the contents of TNF-α、MDA、NO、ONOO-in hepatic tissues were detected.Results:The rat hepatic models were established successfully.In model group:the contents of TNF-α、MDA、NO、ONOO-in hepatic tissues increased significantly.In emodin group:Pathological inj ury of hepatic tissues was alleviated;the contents of TNF-α、MDA、NO、ONOO- decreased obviously. Conclusion:Emodin can reduce oxidative stress in liver and has a protective effect on hepatic firosis rats.