中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2014年
3期
134-136
,共3页
西酞普兰%小剂量%米氮平%脑卒中抑郁症
西酞普蘭%小劑量%米氮平%腦卒中抑鬱癥
서태보란%소제량%미담평%뇌졸중억욱증
citalopram%small dose%mirtazapine%post-stroke depression
目的：探讨小剂量米氮平联合西酞普兰治疗脑卒中后抑郁症（PSD）的临床疗效及安全性。方法将我院收治的114例脑卒中后抑郁症患者，将其随机分为对照组和观察组，每组57例。对照组给予西酞普兰，观察组在此基础上给予小剂量的米氮平。治疗6周，观察并比较两组患者的临床疗效。治疗前后采用汉密尔顿抑郁量表（HAMD）、日常生活能力Barthel指数（BI）量表、临床神经功能缺损评分（SSS）以及不良反应症状量表（TESS）评定疗效及治疗出现的不良反应。结果6周后，两组治疗PSD均有效，观察组的基本治愈率为29.82%，对照组的基本治愈率为21.05%，两组患者间的基本治愈率的差异具有统计学意义（P＜0.05），观察组总有效率（92.98%）明显高于对照组（80.71%），差异有显著性（P＜0.01）。观察组HADM和SSS评分明显低于对照组（P＜0.05），BI评分明显高于对照组（P＜0.05），两组患者的TESS评分无显著性差异，但观察组在失眠及头痛或头晕方面明显低于对照组（P＜0.01）。结论西酞普兰联合小剂量米氮平治疗脑卒中后抑郁症的疗效显著，安全性好，利于神经功能康复，能提高患者的生活质量。
目的：探討小劑量米氮平聯閤西酞普蘭治療腦卒中後抑鬱癥（PSD）的臨床療效及安全性。方法將我院收治的114例腦卒中後抑鬱癥患者，將其隨機分為對照組和觀察組，每組57例。對照組給予西酞普蘭，觀察組在此基礎上給予小劑量的米氮平。治療6週，觀察併比較兩組患者的臨床療效。治療前後採用漢密爾頓抑鬱量錶（HAMD）、日常生活能力Barthel指數（BI）量錶、臨床神經功能缺損評分（SSS）以及不良反應癥狀量錶（TESS）評定療效及治療齣現的不良反應。結果6週後，兩組治療PSD均有效，觀察組的基本治愈率為29.82%，對照組的基本治愈率為21.05%，兩組患者間的基本治愈率的差異具有統計學意義（P＜0.05），觀察組總有效率（92.98%）明顯高于對照組（80.71%），差異有顯著性（P＜0.01）。觀察組HADM和SSS評分明顯低于對照組（P＜0.05），BI評分明顯高于對照組（P＜0.05），兩組患者的TESS評分無顯著性差異，但觀察組在失眠及頭痛或頭暈方麵明顯低于對照組（P＜0.01）。結論西酞普蘭聯閤小劑量米氮平治療腦卒中後抑鬱癥的療效顯著，安全性好，利于神經功能康複，能提高患者的生活質量。
목적：탐토소제량미담평연합서태보란치료뇌졸중후억욱증（PSD）적림상료효급안전성。방법장아원수치적114례뇌졸중후억욱증환자，장기수궤분위대조조화관찰조，매조57례。대조조급여서태보란，관찰조재차기출상급여소제량적미담평。치료6주，관찰병비교량조환자적림상료효。치료전후채용한밀이돈억욱량표（HAMD）、일상생활능력Barthel지수（BI）량표、림상신경공능결손평분（SSS）이급불량반응증상량표（TESS）평정료효급치료출현적불량반응。결과6주후，량조치료PSD균유효，관찰조적기본치유솔위29.82%，대조조적기본치유솔위21.05%，량조환자간적기본치유솔적차이구유통계학의의（P＜0.05），관찰조총유효솔（92.98%）명현고우대조조（80.71%），차이유현저성（P＜0.01）。관찰조HADM화SSS평분명현저우대조조（P＜0.05），BI평분명현고우대조조（P＜0.05），량조환자적TESS평분무현저성차이，단관찰조재실면급두통혹두훈방면명현저우대조조（P＜0.01）。결론서태보란연합소제량미담평치료뇌졸중후억욱증적료효현저，안전성호，리우신경공능강복，능제고환자적생활질량。
Objective To explore the effectiveness and safety of citalopram combined with small dose of mirtazapine for treating post-stroke depression(PSD). Methods 114 patients with post-stroke depression in our hospital were randomly divided into two groups. In the control group, 57 patients were treated with citalopram, and in the observation group, 57 patients received citalopram combined with small dose of mirtazapine.Before treatment and at the end of 6 weeks of treatment, Line Hamilton depression scale(HAMD), daily living skills Barthel index(BI) scale, clinical nerve function defect score(SSS) and adverse reaction symptom scale(TESS) were assessed. Results The treatment for PSD of two groups was effective after 6 weeks. The basic recovery of observation group was 29.82%, the basic recovery of control group was 21.05%.There was significant difference in the basic recovery rate between observation group and the control group(P<0.05). The total effective rate of observation group(92.98%) was significantly higher than the control group(80.71%). The HADM score and SSS score of the observation group were significantly lower than the control group(P<0.05 or 0.01), and BI score was significantly higher than the control group after 6 weeks. There were no significant difference in TESS score between two groups,but the insomnia and headache or dizziness aspects of observation group were significantly lower than the control group(P<0.01). Conclusion Citalopram in combination with small dose of mirtazapine for post-stroke depression has good efficacy and high safety,and can improve recovery of neurological function and activity of daily living of patients .
