CAJ | 학술논문

目的：观察复方丹参滴丸对自发性高血压大鼠（SHR）血小板CD62p和CD63表达的影响。方法按所给药物不同，将80只SHR随机分为复方丹参滴丸加阿司匹林组、复方丹参滴丸组、阿司匹林组和生理盐水对照组各20只，各组持续给药4周，于实验12周末采用流式细胞仪检测治疗后SHR血小板CD62p和CD63的表达水平，并对各组结果进行比较。结果第12周末复方丹参滴丸组血小板CD62p、CD63表达水平低于对照组（P＜0.05），复方丹参滴丸加阿司匹林组CD62p、CD63表达水平较阿司匹林组或复方丹参滴丸组低（P＜0.05）。结论复方丹参滴丸具有抑制血小板CD62p、CD63表达的作用，复方丹参滴丸与阿司匹林合用治疗效果更显著。
목적：관찰복방단삼적환대자발성고혈압대서（SHR）혈소판CD62p화CD63표체적영향。방법안소급약물불동，장80지SHR수궤분위복방단삼적환가아사필림조、복방단삼적환조、아사필림조화생리염수대조조각20지，각조지속급약4주，우실험12주말채용류식세포의검측치료후SHR혈소판CD62p화CD63적표체수평，병대각조결과진행비교。결과제12주말복방단삼적환조혈소판CD62p、CD63표체수평저우대조조（P＜0.05），복방단삼적환가아사필림조CD62p、CD63표체수평교아사필림조혹복방단삼적환조저（P＜0.05）。결론복방단삼적환구유억제혈소판CD62p、CD63표체적작용，복방단삼적환여아사필림합용치료효과경현저。
Objective To observe the effects of composite salvia dropping pill on CD62p and CD63 expression in platelets of spontaneously hypertensive rats. Methods Eighty male spontaneously hypertensive rats were divided into 4 groups:composite salvia dropping pill and aspirin group (n=20)、composite salvia dropping pill group (n=20)、aspirin group (n=20)and control group (n=20). All groups received treat-ment for 4 weeks. Flow cytometric analysis was applied to detect the levels of CD62p at 1 2th week. Results The levels of CD62p and CD63 in composite salvia dropping pill group were significantly lower than those of control group (P<0.05)at the 1 2th weekend. The two indexs in the composite salvia dropping pill and aspi-rin group were obviously lower than those in the aspirin group and the composite salvia dropping pill group (P<0.05). Conclusion Composite salvia dropping pill obviously reduces the levels of CD62p and CD63 in platelets,and the effect of composite salvia dropping pill combined with aspirin is obviously improved.