CAJ | 학술논문

目的：探讨细胞外基质金属蛋白酶诱导因子(CD147)和基质金属蛋白酶-9(MMP-9)在喉鳞癌组织中的表达及临床意义。方法采用免疫组织化学染色法对36例喉鳞癌组织、癌旁组织及15例喉息肉组织中 CD147和 MMP-9的表达进行检测。结果①喉鳞癌组织中CD147的阳性率为83.3%(30/36),高于喉息肉(33.3%,5/15)和癌旁组织(16.7%,6/36)；CD147的表达与喉癌病理分级、临床分期以及淋巴结转移状况有关(P<0.05)。②喉鳞癌组织中MMP-9的阳性率为72.2%(26/36),高于喉息肉(13.3%,2/15)和癌旁组织(5.6%,2/36)；MMP-9的表达与喉鳞癌病理分级、T分级、临床分期以及淋巴结转移状况有关(P<0.05)。③CD147和 MMP-9在喉鳞癌组织中的表达呈正相关(r=0.721,P=0.000)。结论 CD147和 MMP-9在喉鳞癌中有较高的阳性表达,并可能与喉鳞癌的发展和转移有关。
목적：탐토세포외기질금속단백매유도인자(CD147)화기질금속단백매-9(MMP-9)재후린암조직중적표체급림상의의。방법채용면역조직화학염색법대36례후린암조직、암방조직급15례후식육조직중 CD147화 MMP-9적표체진행검측。결과①후린암조직중CD147적양성솔위83.3%(30/36),고우후식육(33.3%,5/15)화암방조직(16.7%,6/36)；CD147적표체여후암병리분급、림상분기이급림파결전이상황유관(P<0.05)。②후린암조직중MMP-9적양성솔위72.2%(26/36),고우후식육(13.3%,2/15)화암방조직(5.6%,2/36)；MMP-9적표체여후린암병리분급、T분급、림상분기이급림파결전이상황유관(P<0.05)。③CD147화 MMP-9재후린암조직중적표체정정상관(r=0.721,P=0.000)。결론 CD147화 MMP-9재후린암중유교고적양성표체,병가능여후린암적발전화전이유관。
Objective To investigate the expressions of CD147 and matrix metalloproteinases-9 (MMP-9)in laryngeal squamous cell carcinoma (LSCC)tissue and their clinical significance.Methods The expressions of CD147 and MMP-9 were analyzed semi-quantitatively by immunohistochemical staining in LSCC and control group tissues.Results ① The positive rate of CD147 was 83.3% (30/36)in LSCC,which was higher than that in laryngeal polyp (33.3%,5/15)and in adjacent normal tissue (16.7%,6/36);it was related to histological grade, clinical stage and lymph node metastasis status (P<0 .0 5 ).② The positive rate of MMP-9 was 7 2 .2% (2 6/3 6 )in LSCC,which was higher than that in laryngeal polyp (13.3%,2/15)and in adjacent normal tissue (5.6%,2/36);it was related to histological grade,T stage,clinical stage and lymph node metastasis status (P<0.05).③ There was a positive correlation between the expressions of CD147 and MMP-9 in LSCC tissue (r=0.721,P=0.000). Conclusion The over-expressions of CD147 and MMP-9 in LSCC may contribute to the development and metastasis of LSCC.