CAJ | 학술논문

目的：探讨白细胞介素12 B(IL-12 B)基因多态性与冠心病发生发展的相关性。方法选择新乡医学院第三附属医院心内科住院的256例冠心病患者为研究组,健康自愿者256例为对照组。应用聚合酶链反应(PCR)及单核苷酸多态性(SNP)技术分析两组 IL-12B基因多态性,并测定冠状动脉狭窄度、内脂素、高敏 C反应蛋白和心功能变化。结果 IL-12B基因 rs15677380和 rs14050311等位基因频率组间差异有统计学意义(χ2=6.19、7.24,P=0.045、0.021),rs15677380 G等位基因和rs14050311 C等位基因为冠心病的高危因素(OR=1.32、1.49)。结论 IL-12B基因与动脉粥样硬化的发生、发展有关,并参与冠心病的发展过程。
목적：탐토백세포개소12 B(IL-12 B)기인다태성여관심병발생발전적상관성。방법선택신향의학원제삼부속의원심내과주원적256례관심병환자위연구조,건강자원자256례위대조조。응용취합매련반응(PCR)급단핵감산다태성(SNP)기술분석량조 IL-12B기인다태성,병측정관상동맥협착도、내지소、고민 C반응단백화심공능변화。결과 IL-12B기인 rs15677380화 rs14050311등위기인빈솔조간차이유통계학의의(χ2=6.19、7.24,P=0.045、0.021),rs15677380 G등위기인화rs14050311 C등위기인위관심병적고위인소(OR=1.32、1.49)。결론 IL-12B기인여동맥죽양경화적발생、발전유관,병삼여관심병적발전과정。
Objective To study the relationship between the polymorphism of interleukin-12B (IL-12B)gene and coronary heart disease.Methods We recruited 256 patients with coronary heart disease admitted to our department as the study group and 256 normal subjects as the control group.The polymorphism of IL-12B gene was detected by polymerase chain reaction and single nucleotide polymorphism.Coronary artery stenosis,visfatin,high sensitive C reactive protein and cardiac function were determined.Results The difference in rs15677380 and rs14050311 allele frequencies between the study group and the control group was significant (χ2 =6.19,7.24,P=0.045,0.021).The G allele of rs15677380 and C allele of rs14050311 were risk factors for coronary heart disease (OR=1.32,1.49).Conclusion IL-12B gene is associated with the occurrence and development of carotid atherosclerosis and participates in the development of coronary heart disease.