CAJ | 학술논문

非酒精性脂肪性肝病（NAFLD）在世界范围内患病率逐渐升高，“二次打击学说”发病机制已经被认可，但是具体的病理生理学发病机制还不完全清楚。近期，已有大量研究的新观点来解释肠道菌群在 NAFLD 发病机制中的作用，包括调节肠粘膜通透性、低水平炎症反应和免疫平衡，调节饮食胆碱代谢，调节胆汁酸代谢和增加细菌产生的内源性乙醇等。这些因素在分子水平上解释了肠道菌群如何促发 NAFLD 的发生，并进一步诱导其向非酒精性脂肪性肝炎（NASH）进展。
비주정성지방성간병（NAFLD）재세계범위내환병솔축점승고，“이차타격학설”발병궤제이경피인가，단시구체적병리생이학발병궤제환불완전청초。근기，이유대량연구적신관점래해석장도균군재 NAFLD 발병궤제중적작용，포괄조절장점막통투성、저수평염증반응화면역평형，조절음식담감대사，조절담즙산대사화증가세균산생적내원성을순등。저사인소재분자수평상해석료장도균군여하촉발 NAFLD 적발생，병진일보유도기향비주정성지방성간염（NASH）진전。
Non-alcoholic fatty liver diseases (NAFLD) has an increasing worldwide prevalence. A‘two-hit’ mechanism has been accepted,however,its pathogenesis remains to be clarified. Recently,some new findings about gut microbiota in NAFLD have emerged. It might be involved in gut permeability,low-grade inflammation and immune inbalance,and it is believed that it modulates dietary choline metabolism,regulates bile acid metabolism and produces endogenous ethanol. All of these factors are molecular mechanisms by which the microbiota can induce NAFLD or has some roles in the process from NAFLD to overt non-alcoholic steatohepatitis. This review summarizes the main literature findings about the relationships between gut microbiota and NAFLD.