CAJ | 학술논문

作为代谢综合征的肝脏表现，非酒精性脂肪性肝病（NAFLD）的主要特征为胰岛素抵抗（IR）和肝脂肪沉积。脂肪细胞因子作为脂肪细胞分泌的多肽，在 NAFLD 和 IR 的发病中发挥着重要的作用。本文综述了瘦素、脂联素、视黄醇结合蛋白4、成纤维细胞生长因子21和趋化素等新发现的细胞因子与 NAFLD 发病之间的关系。
작위대사종합정적간장표현，비주정성지방성간병（NAFLD）적주요특정위이도소저항（IR）화간지방침적。지방세포인자작위지방세포분비적다태，재 NAFLD 화 IR 적발병중발휘착중요적작용。본문종술료수소、지련소、시황순결합단백4、성섬유세포생장인자21화추화소등신발현적세포인자여 NAFLD 발병지간적관계。
Nonalcoholic fatty liver disease(NAFLD) is a part of hepatic manifestation of the metabolic syndrome. Its main features are fat deposition in liver and insulin resistance (IR). Adipokines, a group of polypeptides secreted by adipocyte cells, play an important role in the pathogenesis of NAFLD and IR. In this paper,the focus is emphasized on the roles of adipokines in NAFLD,such as leptin, adiponectin, retinol binding protein 4,fibroblast growth factor 21,chemerin and other emerging factors.