中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
4期
568-571
,共4页
张蓬华%梁俊%张静%董永成
張蓬華%樑俊%張靜%董永成
장봉화%량준%장정%동영성
水飞蓟宾%脂肪乳%制备%体外释药
水飛薊賓%脂肪乳%製備%體外釋藥
수비계빈%지방유%제비%체외석약
Silybin%Lipid emulsions%Preparation%Release in vitro
目的：制备水飞蓟宾脂肪乳并对其体外释放进行考察。方法：在单因素试验的基础上,采用正交试验设计优化水飞蓟宾脂肪乳处方。采用高压均质法制备水飞蓟宾脂肪乳。结果：脂肪乳平均粒径为(74.42±14) nm,粒径分布系数( PDI)为0.106,Zeta电位为(-30.2±2.13)mV,pH为6.48±0.04,包封率(91.45±0.0052)%,体外12 h内,累积释放原药的90%左右。结论：本试验获得了较理想的水飞蓟宾脂肪乳,其体外释放具有显著的缓释作用。
目的：製備水飛薊賓脂肪乳併對其體外釋放進行攷察。方法：在單因素試驗的基礎上,採用正交試驗設計優化水飛薊賓脂肪乳處方。採用高壓均質法製備水飛薊賓脂肪乳。結果：脂肪乳平均粒徑為(74.42±14) nm,粒徑分佈繫數( PDI)為0.106,Zeta電位為(-30.2±2.13)mV,pH為6.48±0.04,包封率(91.45±0.0052)%,體外12 h內,纍積釋放原藥的90%左右。結論：本試驗穫得瞭較理想的水飛薊賓脂肪乳,其體外釋放具有顯著的緩釋作用。
목적：제비수비계빈지방유병대기체외석방진행고찰。방법：재단인소시험적기출상,채용정교시험설계우화수비계빈지방유처방。채용고압균질법제비수비계빈지방유。결과：지방유평균립경위(74.42±14) nm,립경분포계수( PDI)위0.106,Zeta전위위(-30.2±2.13)mV,pH위6.48±0.04,포봉솔(91.45±0.0052)%,체외12 h내,루적석방원약적90%좌우。결론：본시험획득료교이상적수비계빈지방유,기체외석방구유현저적완석작용。
Objective:To prepare silybin ( SLB) lipid emulsions and evaluate the drug release behavior in vitro. Methods:Silybin lipid emulsions were prepared by high-pressure homogenization method. Under the guidance of single-factor test, the best formula of SLB lipid emulsions was obtained by orthogonal design. Results:The encapsulation efficiency of SLB lipid emulsions prepared by the optimal formula was (91. 45 ± 0. 005 2) % with the particle size of (74. 42 ± 14)nm and PDI of 0. 106, Zeta potential of ( -30. 2 ± 2. 13)mV and pH of (6. 48 ± 0. 04). The drug release of SLB lipid emulsions was up to 90% within 12 hours. Conclusion:The opti-mized preparation of SLB with sustained-release property is obtained successfully.
