中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
4期
553-555
,共3页
唐跃年%陈霁晖%林志燕%魏昕%陈婷%张健%陆晓彤%金樑%孙朝荣%胡松浩%杨传敏%严云
唐躍年%陳霽暉%林誌燕%魏昕%陳婷%張健%陸曉彤%金樑%孫朝榮%鬍鬆浩%楊傳敏%嚴雲
당약년%진제휘%림지연%위흔%진정%장건%륙효동%금량%손조영%호송호%양전민%엄운
麻黄碱%射干合剂%排泄%药动学
痳黃堿%射榦閤劑%排洩%藥動學
마황감%사간합제%배설%약동학
Ephedrine hydrochloride%Shegan mixtures%Excretion%Pharmacokinetics
目的：给大鼠灌胃射干合剂后,了解射干合剂中盐酸麻黄碱在大鼠血清中药动学。方法：采用液质联用技术测定盐酸麻黄碱含量,大鼠灌胃射干合剂(1.0 ml/100 g)后,盐酸麻黄碱血浓变化,采用药动学软件计算,求出盐酸麻黄碱的药动学参数；采用代谢笼技术,计算射干合剂中盐酸麻黄碱在24h内大鼠尿液、粪便中回收率。结果：得到盐酸麻黄碱的药动学参数为Tmax：(1.30±0.23)h,T1/2：(21.17±1.35)h,Cmax：(278.86±46.41)ng·ml-1,AUC0~∞：(1221.98±412.64)ng·ml-1,Vc/F：(1.70±0.15)L；盐酸麻黄碱在24 h内可在尿中回收85.66%；粪便中未能测得盐酸麻黄碱。结论：盐酸麻黄碱在大鼠体内24 h基本排泄完；服用射干合剂不会造成体内麻黄碱的蓄积；大鼠体内盐酸麻黄碱主要经肾脏排泄。
目的：給大鼠灌胃射榦閤劑後,瞭解射榦閤劑中鹽痠痳黃堿在大鼠血清中藥動學。方法：採用液質聯用技術測定鹽痠痳黃堿含量,大鼠灌胃射榦閤劑(1.0 ml/100 g)後,鹽痠痳黃堿血濃變化,採用藥動學軟件計算,求齣鹽痠痳黃堿的藥動學參數；採用代謝籠技術,計算射榦閤劑中鹽痠痳黃堿在24h內大鼠尿液、糞便中迴收率。結果：得到鹽痠痳黃堿的藥動學參數為Tmax：(1.30±0.23)h,T1/2：(21.17±1.35)h,Cmax：(278.86±46.41)ng·ml-1,AUC0~∞：(1221.98±412.64)ng·ml-1,Vc/F：(1.70±0.15)L；鹽痠痳黃堿在24 h內可在尿中迴收85.66%；糞便中未能測得鹽痠痳黃堿。結論：鹽痠痳黃堿在大鼠體內24 h基本排洩完；服用射榦閤劑不會造成體內痳黃堿的蓄積；大鼠體內鹽痠痳黃堿主要經腎髒排洩。
목적：급대서관위사간합제후,료해사간합제중염산마황감재대서혈청중약동학。방법：채용액질련용기술측정염산마황감함량,대서관위사간합제(1.0 ml/100 g)후,염산마황감혈농변화,채용약동학연건계산,구출염산마황감적약동학삼수；채용대사롱기술,계산사간합제중염산마황감재24h내대서뇨액、분편중회수솔。결과：득도염산마황감적약동학삼수위Tmax：(1.30±0.23)h,T1/2：(21.17±1.35)h,Cmax：(278.86±46.41)ng·ml-1,AUC0~∞：(1221.98±412.64)ng·ml-1,Vc/F：(1.70±0.15)L；염산마황감재24 h내가재뇨중회수85.66%；분편중미능측득염산마황감。결론：염산마황감재대서체내24 h기본배설완；복용사간합제불회조성체내마황감적축적；대서체내염산마황감주요경신장배설。
Objective: To determine the pharmacokinetics of ephedrine hydrochloride in rats after intragastric administration of Shegan mixtures. Methods:Shegan mixtures (1. 0 ml/100 g) were administered to each rat by gavage. Blood samples were collected after the administration. Plasma concentration of ephedrine hydrochloride was determined by LC-MS/MS. The pharmacokinetic parame-ters of ephedrine hydrochloride were obtained using the pharmacokinetic software. Urine and fecal samples were collected in 24 hours after the administration using metabolic cage to determine the recovery of ephedrine hydrochloride. Results: The pharmacokinetic pa-rameters of ephedrine hydrochloride were as follows:Tmax of (1. 30 ± 0. 23)h,T1/2 of (21. 17 ± 1. 35)h, Cmax of (278. 86 ± 46. 41)ng ·ml-1,AUC0~∞ of (1221.98 ±412.64)ng·ml-1 and Vc/F of (1.70 ±0.15)L. Totally 85.66% ephedrine hydrochloride could be recovered from urine in 24 hours after the administration;however, it was not detected in the fecal samples. Conclusion: Most of e-phedrine hydrochloride is excreted through kidney in 24h,therefore, Shegan mixtures can't cause the accumulation of ephedrine hydro-chloride in rats.
