CAJ | 학술논문

滤泡辅助T（ T follicular helper ， Tfh）细胞是一种新的CD4＋辅助性T细胞亚群，能持续分泌趋化因子受体5（CXC receptor 5， CXCR5），后者与趋化因子CXC配体13（chemokine CXC ligand 13， CXCL13）结合后使Tfh细胞迁移至滤泡区参与生发中心的形成。在可诱导共刺激分子（inducible T cell co-stimulator， ICOS）与CD40L共同作用下，Tfh细胞分泌关键效应因子白细胞介素-21（ interferon-21， IL-21）发挥重要的免疫作用，重组人 B 细胞淋巴瘤蛋白（ B-cell lymphoma 6 protein， Bcl-6）是其重要的转录因子。越来越多的研究表明Tfh细胞及其细胞因子在肿瘤以及自身免疫性疾病中发挥着重要的作用，然而对其在肿瘤中的发病机制并不十分清楚，有待于进一步去探索。文中主要对Tfh细胞的发育分化、主要特性、相关因子与肿瘤之间的关系等方面进行综述。
려포보조T（ T follicular helper ， Tfh）세포시일충신적CD4＋보조성T세포아군，능지속분비추화인자수체5（CXC receptor 5， CXCR5），후자여추화인자CXC배체13（chemokine CXC ligand 13， CXCL13）결합후사Tfh세포천이지려포구삼여생발중심적형성。재가유도공자격분자（inducible T cell co-stimulator， ICOS）여CD40L공동작용하，Tfh세포분비관건효응인자백세포개소-21（ interferon-21， IL-21）발휘중요적면역작용，중조인 B 세포림파류단백（ B-cell lymphoma 6 protein， Bcl-6）시기중요적전록인자。월래월다적연구표명Tfh세포급기세포인자재종류이급자신면역성질병중발휘착중요적작용，연이대기재종류중적발병궤제병불십분청초，유대우진일보거탐색。문중주요대Tfh세포적발육분화、주요특성、상관인자여종류지간적관계등방면진행종술。
T follicular helper cells (Tfh cells) are new CD4 +T helper cell subsets.They can continuously secret CXC recep-tor 5(CXCR5)which can combine with CXC ligand 13(CXCL13)and guide Tfh cells to migrate to the follicular area and participate in the formation of germinal centers.Under the combined action of inducible T cell co stimulator (ICOS)and CXCL13, Tfh cells secrete key effect factor--interferon-21 (IL-2), which plays a significant role in immunity.B cell lymphoma 6 protein (Bcl-6) is an important transcription factor in this secretion .More and more studies have indicated that Tfh cells and their cytokines play an important role in ( the formation and development of ) autoimmune diseases and tumor , but the pathogenesis is not clear and needs further experiments to explore .In this paper , we summarize the development , differentiation and main characteristics of Tfh cells and the relationship between its related factors and tumor .