CAJ | 학술논문

目的：探讨急性胰腺炎（ AP ）患者血液 D-二聚体及炎性因子的变化情况及其临床意义。方法急性胰腺炎患者107例，其中44例为重症急性胰腺炎（ SAP）患者，63例为轻症急性胰腺炎（ MAP）患者，检测其治疗前后血清D-二聚体、白细胞介素-6（IL-6）、C-反应蛋白（CRP）水平，并与121例健康对照组比较。结果与健康对照组比较，SAP组、MAP组的D-二聚体、IL-6和CRP水平均明显升高（ P＜0．05）；SAP组的D-二聚体、IL-6和CRP水平均高于MAP组（P＜0．05）；107例患者治疗后上述指标水平显著降低（P＜0．05）。结论血清D-二聚体、IL-6和CRP水平对AP的诊断及严重程度的预测、临床疗效的评价具有一定价值。
목적：탐토급성이선염（ AP ）환자혈액 D-이취체급염성인자적변화정황급기림상의의。방법급성이선염환자107례，기중44례위중증급성이선염（ SAP）환자，63례위경증급성이선염（ MAP）환자，검측기치료전후혈청D-이취체、백세포개소-6（IL-6）、C-반응단백（CRP）수평，병여121례건강대조조비교。결과여건강대조조비교，SAP조、MAP조적D-이취체、IL-6화CRP수평균명현승고（ P＜0．05）；SAP조적D-이취체、IL-6화CRP수평균고우MAP조（P＜0．05）；107례환자치료후상술지표수평현저강저（P＜0．05）。결론혈청D-이취체、IL-6화CRP수평대AP적진단급엄중정도적예측、림상료효적평개구유일정개치。
Objective To investigate the changes and clinical value of D-dimer(DD) and inflammatory cytokines in patients with acute pancreatitis(AP).Methods Among 107 AP patients,there were 44 with severe AP(SAP) and 63 with mild AP(MAP).The levels of DD,interleukin-6(IL-6),C-reactive protein(CRP) were detected in 107 AP before and after treatment,which were compared with 121 health controls.Results Compared with the health controls,the levels of DD,IL-6 and CRP in SAP and MAP groups increased significantly (P<0.05).The levels of DD,IL-6 and CRP in SAP group were significantly higher than those in MAP group (P<0.05).The levels of indexes above decreased significantly after treatment ( P<0 .05 ) .Conclusion The serum levels of DD ,IL-6 and CRP may be valuable in the diagnosis and prediction of development of acute pancreatitis as well as evaluation of clinical efficacy of acute pancreatitis .